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Antitumor and Antibacterial Activity of Ni(II), Cu(II), Ag(I), and Hg(II) Complexes with Ligand Derived from Thiosemicarbazones: Characterization and Theoretical Studies

التفاصيل البيبلوغرافية
العنوان: Antitumor and Antibacterial Activity of Ni(II), Cu(II), Ag(I), and Hg(II) Complexes with Ligand Derived from Thiosemicarbazones: Characterization and Theoretical Studies
المؤلفون: Heba Alshater, Ahlam I. Al-Sulami, Samar A. Aly, Ehab M. Abdalla, Mohamed A. Sakr, Safaa S. Hassan
المصدر: Molecules, Vol 28, Iss 6, p 2590 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Organic chemistry
مصطلحات موضوعية: complexes, DFT, antitumor, antibacterial, molecular docking, Organic chemistry, QD241-441
الوصف: Four new complexes (Ni2+, Cu2+, Ag+, and Hg2+) were prepared from the ligand N-(4-chlorophenyl)-2-(phenylglycyl)hydrazine-1-carbothioamide (H2L). Analytical and spectroscopic techniques were used to clarify the structural composition of the new chelates. In addition, all chelates were tested against bacterial strains and the HepG2 cell line to determine their antiseptic and carcinogenic properties. The Ni(II) complex was preferable to the other chelates. Molecular optimization revealed that H2L had the highest reactivity, followed by Hg-chelate, Ag-chelate, Ni-chelate, and Cu-chelate. Moreover, molecular docking was investigated against two different proteins: the ribosyltransferase enzyme (code: 3GEY) and the EGFR tyrosine kinase receptor (code: 1m17).
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 28062590
1420-3049
Relation: https://www.mdpi.com/1420-3049/28/6/2590; https://doaj.org/toc/1420-3049
DOI: 10.3390/molecules28062590
URL الوصول: https://doaj.org/article/d6a09a404aff4e488a6d8759120e4f06
رقم الأكسشن: edsdoj.6a09a404aff4e488a6d8759120e4f06
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:28062590
14203049
DOI:10.3390/molecules28062590