دورية أكاديمية
A cluster of Candida parapsilosis displaying fluconazole-trailing in a neonatal intensive care unit successfully contained by multiple infection-control interventions
| العنوان: | A cluster of Candida parapsilosis displaying fluconazole-trailing in a neonatal intensive care unit successfully contained by multiple infection-control interventions |
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| المؤلفون: | Hiroaki Baba, Hajime Kanamori, Asami Nakayama, Takami Sato, Makoto Katsumi, Takae Chida, Shinobu Ikeda, Rio Seki, Teppei Arai, Katsuhiko Kamei, Koichi Tokuda |
| المصدر: | Antimicrobial Stewardship & Healthcare Epidemiology, Vol 4 (2024) |
| بيانات النشر: | Cambridge University Press, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Infectious and parasitic diseases LCC:Public aspects of medicine |
| مصطلحات موضوعية: | Infectious and parasitic diseases, RC109-216, Public aspects of medicine, RA1-1270 |
| الوصف: | Abstract Objective: This study aimed to investigate and contain a cluster of invasive candidiasis cases caused by fluconazole-resistant Candida parapsilosis (FRC) in a neonatal intensive care unit. Methods: Active surveillance was initiated. Direct observations of hand-hygiene compliance (HHC) among staff were conducted before and after the implementation of hand-hygiene (HH) education. Thirty-five environmental cultures were obtained. Phylogenetic analysis of FRC was performed using Fourier-transform infrared spectroscopy and microsatellite genotyping. Results: A total of 14 patients (mean birth weight = 860 g, gestational age = 25 weeks) infected with FRC were identified using the fully automated analyzer, including 5 with clinical infection (three with catheter-related bloodstream infection, one with cutaneous infection, and one with fatal peritonitis) and 9 with colonization. The HHC rate in nurses before performing a sterile or aseptic procedure significantly improved after the HH education (P < .05). Sinks near the patients were contaminated with FRC. All FRC strains were confirmed to be susceptible to fluconazole using the CLSI method, and the microdilution procedure indicated a trailing effect. Phylogenetic analysis showed that all the fluconazole-trailing isolates from patients were clustered together and had the same genotype. Sinks were successfully decontaminated using accelerated hydrogen peroxide and drainage pipes were replaced. Ultraviolet-C decontamination was applied in the milk preparation room. No new cases were detected after the education and disinfection interventions. Conclusions: Sinks are an important reservoir of C. parapsilosis. Active surveillance, environmental hygiene, and constant staff education on maintaining a high level of HHC are necessary to limit the spread of C. parapsilosis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2732-494X |
| Relation: | https://www.cambridge.org/core/product/identifier/S2732494X24000779/type/journal_article; https://doaj.org/toc/2732-494X |
| DOI: | 10.1017/ash.2024.77 |
| URL الوصول: | https://doaj.org/article/6a0f4771736a4c33b97fd43492eed5c1 |
| رقم الأكسشن: | edsdoj.6a0f4771736a4c33b97fd43492eed5c1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2732494X |
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| DOI: | 10.1017/ash.2024.77 |