دورية أكاديمية
The Significance of MGMT Promoter Methylation Status in Diffuse Glioma
العنوان: | The Significance of MGMT Promoter Methylation Status in Diffuse Glioma |
---|---|
المؤلفون: | Nikola Jovanović, Milica Lazarević, Vladimir J. Cvetković, Vesna Nikolov, Jelena Kostić Perić, Milena Ugrin, Sonja Pavlović, Tatjana Mitrović |
المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 21, p 13034 (2022) |
بيانات النشر: | MDPI AG, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | diffuse glioma, glioblastoma, MGMT, IDH1, IDH2, MSP, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | A single-institution observational study with 43 newly diagnosed diffuse gliomas defined the isocitrate dehydrogenase 1 and 2 (IDH1/2) gene mutation status and evaluated the prognostic relevance of the methylation status of the epigenetic marker O6-methylguanine-DNA methyltransferase (MGMT). Younger patients (p = 0.33). On the other side, real-time methylation-specific PCR (qMSP) revealed 23 tumor samples (54%) that were positively methylated without association with OS (p = 0.15). A combined MSP analysis, which included the homogenous cohort of 24 patients (>50 years with surgical resection and IDH1/2-wildtype diffuse glioma), distinguished 10 (41.6%) methylated samples from 14 (58.4%) unmethylated samples. Finally, significant correlation between OS and methylation status was noticed (p ≈ 0.05). The OS of the hypermethylated group was 9.6 ± 1.77 months, whereas the OS of the unmethylated group was 5.43 ± 1.04 months. Our study recognized the MGMT promoter methylation status as a positive prognostic factor within the described homogenous cohort, although further verification in a larger population of diffuse gliomas is required. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 1661-6596 |
Relation: | https://www.mdpi.com/1422-0067/23/21/13034; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms232113034 |
URL الوصول: | https://doaj.org/article/c6a4270295364b2ca1898e4710ca324c |
رقم الأكسشن: | edsdoj.6a4270295364b2ca1898e4710ca324c |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 16616596 |
---|---|
DOI: | 10.3390/ijms232113034 |