دورية أكاديمية
Risk of Diabetes in Patients with Long-Standing Graves’ Disease: A Longitudinal Study
| العنوان: | Risk of Diabetes in Patients with Long-Standing Graves’ Disease: A Longitudinal Study |
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| المؤلفون: | Eyun Song, Min Ji Koo, Eunjin Noh, Soon Young Hwang, Min Jeong Park, Jung A Kim, Eun Roh, Kyung Mook Choi, Sei Hyun Baik, Geum Joon Cho, Hye Jin Yoo |
| المصدر: | Endocrinology and Metabolism, Vol 36, Iss 6, Pp 1277-1286 (2021) |
| بيانات النشر: | Korean Endocrine Society, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| مصطلحات موضوعية: | hyperthyroidism, graves disease, diabetes mellitus, antithyroid agents, radioiodine ablation, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Background The detrimental effects of excessive thyroid hormone on glucose metabolism have been widely investigated. However, the risk of diabetes in patients with long-standing hyperthyroidism, especially according to treatment modality, remains uncertain, with few longitudinal studies. Methods The risk of diabetes in patients with Graves’ disease treated with antithyroid drugs (ATDs) for longer than the conventional duration (≥2 years) was compared with that in age-and sex-matched controls. The risk was further compared according to subsequent treatment modalities after a 24-month course of ATD: continuation of ATD (ATD group) vs. radioactive iodine ablation (RIA) group. Results A total of 4,593 patients were included. Diabetes was diagnosed in 751 (16.3%) patients over a follow-up of 7.3 years. The hazard ratio (HR) for diabetes, after adjusting for various known risk factors, was 1.18 (95% confidence interval [CI], 1.10 to 1.28) in patients with hyperthyroidism. Among the treatment modality groups, the RIA group (n=102) had a higher risk of diabetes than the ATD group (n=4,491) with HR of 1.56 (95% CI, 1.01 to 2.42). Further, the risk of diabetes increased with an increase in the ATD treatment duration (P for trend=0.019). Conclusion The risk of diabetes was significantly higher in patients with long-standing Graves’ disease than in the general population, especially in patients who underwent RIA and prolonged ATD treatment. Special attention to hyperglycemia during follow-up along with effective control of hyperthyroidism may be necessary to reduce the risk of diabetes in these patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Korean |
| تدمد: | 2093-596X 2093-5978 |
| Relation: | http://www.e-enm.org/upload/pdf/enm-2021-1251.pdf; https://doaj.org/toc/2093-596X; https://doaj.org/toc/2093-5978 |
| DOI: | 10.3803/EnM.2021.1251 |
| URL الوصول: | https://doaj.org/article/6a463ec04e704db39491ed7ece96a0b2 |
| رقم الأكسشن: | edsdoj.6a463ec04e704db39491ed7ece96a0b2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2093596X 20935978 |
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| DOI: | 10.3803/EnM.2021.1251 |