دورية أكاديمية
Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma
| العنوان: | Transcription factor 3 promotes migration and invasion potential and maintains cancer stemness by activating ID1 expression in esophageal squamous cell carcinoma |
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| المؤلفون: | Zhao-Xing Li, Ming-Chuang Sun, Kang Fang, Zi-Ying Zhao, Zhu-Yun Leng, Ze-Hua Zhang, Ai-Ping Xu, Yuan Chu, Li Zhang, Jingjing Lian, Tao Chen, Mei-Dong Xu |
| المصدر: | Cancer Biology & Therapy, Vol 24, Iss 1 (2023) |
| بيانات النشر: | Taylor & Francis Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | tcf3, id1, cancer stem cell, esophageal squamous cell carcinoma, cancer stemness, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Transcription factor 3 (TCF3) is a member of the basic Helix – Loop – Helix (bHLH) transcription factor (TF) family and is encoded by the TCF3 gene (also known as E2A). It has been shown that TCF3 functions as a key transcription factor in the pathogenesis of several human cancers and plays an important role in stem cell maintenance and carcinogenesis. However, the effect of TCF3 in the progression of esophageal squamous cell carcinoma (ESCC) is poorly known. In our study, TCF3 was found to express highly and correlated with cancer stage and prognosis. TCF3 was shown to promote ESCC invasion, migration, and drug resistance both from the results of in vivo and in vitro assays. Moreover, further studies suggested that TCF3 played these roles through transcriptionally regulating Inhibitor of DNA binding 1(ID1). Notably, we also found that TCF3 or ID1 was associated with ESCC stemness. Furthermore, TCF3 was correlated with the expression of cancer stemness markers CD44 and CD133. Therefore, maintaining cancer stemness might be the underlying mechanism that TCF3 transcriptionally regulated ID1 and further promoted ESCC progression and drug resistance. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1538-4047 1555-8576 15384047 |
| Relation: | https://doaj.org/toc/1538-4047; https://doaj.org/toc/1555-8576 |
| DOI: | 10.1080/15384047.2023.2246206 |
| URL الوصول: | https://doaj.org/article/6a55deecf4524c9f9d2f7e60edff80b0 |
| رقم الأكسشن: | edsdoj.6a55deecf4524c9f9d2f7e60edff80b0 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 15384047 15558576 |
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| DOI: | 10.1080/15384047.2023.2246206 |