دورية أكاديمية
Characteristics and predictive factors of visual function improvements after monocular perceptual learning in amblyopia
| العنوان: | Characteristics and predictive factors of visual function improvements after monocular perceptual learning in amblyopia |
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| المؤلفون: | Yunsi He, Lei Feng, Yusong Zhou, Yijing Zhuang, Zixuan Xu, Ying Yao, Xiaolan Chen, Rengang Jiang, Junpeng Yuan, Qingqing Ye, Yun Wen, Yu Jia, Jing Liu, Jinrong Li |
| المصدر: | Heliyon, Vol 9, Iss 6, Pp e17281- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | Perceptual learning, Amblyopia, Visual plasticity, Contrast sensitivity function, Predict outcomes, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | Monocular perceptual learning has shown promising performance in restoring visual function in amblyopes beyond the critical period in the laboratory. However, the treatment outcome is variable and indeterminate in actual clinical and neuroscientific practice. We aimed to explore the efficacy of monocular perceptual learning in the clinical setting. By combining continuous monitoring of perceptual learning and clinical measurements, we evaluated the efficacy and characteristics of visual acuity and contrast sensitivity function improvement and further explored the individualized effect after perceptual learning. Amblyopes (average age:17 ± 7 years old) were trained in a monocular two-alternative forced choice identification task at the 50% contrast threshold of the amblyopic eye for 10–15 days. We found that monocular perceptual learning improves both visual acuity and contrast sensitivity function in amblyopia. The broader activation of spatial contrast sensitivity, with a significant improvement in lower spatial frequencies, contributed to improving visual acuity. Visual acuity changes in the early stage can predict the endpoint treatment outcomes. Our results confirm the efficacy of monocular perceptual learning and suggest potential predictors of training outcomes to assist in the future management of clinical intervention and vision neuroscience research in amblyopia beyond the critical period of visual plasticity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023044894; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e17281 |
| URL الوصول: | https://doaj.org/article/6aaa8e476f264d27aafb17b51fdfade0 |
| رقم الأكسشن: | edsdoj.6aaa8e476f264d27aafb17b51fdfade0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2023.e17281 |