دورية أكاديمية
Role of prophylactic tranexamic acid in reducing blood loss during cesarean section: A double-blind placebo-controlled randomized controlled trial
| العنوان: | Role of prophylactic tranexamic acid in reducing blood loss during cesarean section: A double-blind placebo-controlled randomized controlled trial |
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| المؤلفون: | Nutan Sinha, Sarita Rajbhar, Pushpawati Thakur, Sarita Agrawal, Vinita Singh |
| المصدر: | Journal of Family Medicine and Primary Care, Vol 13, Iss 5, Pp 1760-1765 (2024) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | antifibrinolytics, maternal morbidity, maternal mortality, obstetric hemorrhage, postpartum hemorrhage, tranexamic acid, Medicine |
| الوصف: | Background: Postpartum hemorrhage (PPH) is defined by the World Health Organization as blood loss of ≥500 mL within 24 h of delivery. Globally, hemorrhage accounts for 27.1% of maternal deaths, making it the leading direct cause of maternal death. PPH has been identified in more than two-thirds of reported hemorrhage-related deaths, causing 38% of maternal deaths in India. Tranexamic acid, an antifibrinolytic, has been used to control bleeding after PPH is identified. Materials and Methods: Antenatal women admitted for elective cesarean section were randomized into two arms: the case group (received one gram of tranexamic acid 20 min prior to skin incision) and the control group (received a placebo), each group consisting of 36 participants. Clinical Trials Registry – India (CTRI) registration number – CTRI/2021/02/031579. Results: The mean (±standard deviation [SD]) intraoperative blood loss in the case group was 241.25 (±67.83) mL, and in the control group, it was 344.92 (±146.67) mL (P = 0.001), while postoperative blood loss did not differ significantly between the groups (P = 0.1470). In terms of the difference in hemoglobin, there was a significant difference between the two groups (P = 0.001). No significant maternal or neonatal side effects were found. Conclusion: Preoperative tranexamic acid, when given in elective cesarean section, significantly reduces intraoperative blood loss. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2249-4863 2278-7135 |
| Relation: | https://journals.lww.com/10.4103/jfmpc.jfmpc_1541_23; https://doaj.org/toc/2249-4863; https://doaj.org/toc/2278-7135 |
| DOI: | 10.4103/jfmpc.jfmpc_1541_23 |
| URL الوصول: | https://doaj.org/article/6b38238402984149a161918d3b1ce5ab |
| رقم الأكسشن: | edsdoj.6b38238402984149a161918d3b1ce5ab |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22494863 22787135 |
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| DOI: | 10.4103/jfmpc.jfmpc_1541_23 |