دورية أكاديمية
Antibiotic-induced accumulation of lipid II synergizes with antimicrobial fatty acids to eradicate bacterial populations
| العنوان: | Antibiotic-induced accumulation of lipid II synergizes with antimicrobial fatty acids to eradicate bacterial populations |
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| المؤلفون: | Ashelyn E Sidders, Katarzyna M Kedziora, Melina Arts, Jan-Martin Daniel, Stefania de Benedetti, Jenna E Beam, Duyen T Bui, Joshua B Parsons, Tanja Schneider, Sarah E Rowe, Brian P Conlon |
| المصدر: | eLife, Vol 12 (2023) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | Staphylococcus aureus, antibiotic, adjuvant, lipid II, cell wall biosynthesis, unsaturated fatty acids, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Antibiotic tolerance and antibiotic resistance are the two major obstacles to the efficient and reliable treatment of bacterial infections. Identifying antibiotic adjuvants that sensitize resistant and tolerant bacteria to antibiotic killing may lead to the development of superior treatments with improved outcomes. Vancomycin, a lipid II inhibitor, is a frontline antibiotic for treating methicillin-resistant Staphylococcus aureus and other Gram-positive bacterial infections. However, vancomycin use has led to the increasing prevalence of bacterial strains with reduced susceptibility to vancomycin. Here, we show that unsaturated fatty acids act as potent vancomycin adjuvants to rapidly kill a range of Gram-positive bacteria, including vancomycin-tolerant and resistant populations. The synergistic bactericidal activity relies on the accumulation of membrane-bound cell wall intermediates that generate large fluid patches in the membrane leading to protein delocalization, aberrant septal formation, and loss of membrane integrity. Our findings provide a natural therapeutic option that enhances vancomycin activity against difficult-to-treat pathogens, and the underlying mechanism may be further exploited to develop antimicrobials that target recalcitrant infection. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/80246; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.80246 |
| URL الوصول: | https://doaj.org/article/6b73aca696fd4a22bd95efcb07639f3f |
| رقم الأكسشن: | edsdoj.6b73aca696fd4a22bd95efcb07639f3f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.80246 |