دورية أكاديمية
Erythrocyte membrane skeleton inhibits nanoparticle endocytosis
| العنوان: | Erythrocyte membrane skeleton inhibits nanoparticle endocytosis |
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| المؤلفون: | Xinli Gao, Tongtao Yue, Falin Tian, Zhiping Liu, Xianren Zhang |
| المصدر: | AIP Advances, Vol 7, Iss 6, Pp 065303-065303-11 (2017) |
| بيانات النشر: | AIP Publishing LLC, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Physics |
| مصطلحات موضوعية: | Physics, QC1-999 |
| الوصف: | Red blood cells (RBCs), also called erythrocytes, have been experimentally proposed in recent decades as the biological drug delivery systems through entrapping certain drugs by endocytosis. However, the internalization pathway of endocytosis seems to conflict with the robust mechanical properties of RBCs that is induced by the spectrin-actin network of erythrocyte membrane skeleton. In this work, we employed a minimum realistic model and the dissipative particle dynamics method to investigate the influence of the spectrin-actin membrane skeleton on the internalization of nanoparticles (NPs). Our simulations show that the existence of skeleton meshwork indeed induces an inhibiting effect that effectively prevents NPs from internalization. The inhibiting effect is found to depend on the membrane-NP attraction, skeleton tension and relative size of the NP to the membrane skeleton mesh. However, our simulations also demonstrate that there are two possibilities for successful internalization of NPs in the presence of the membrane skeleton. The first case is for NPs that has a much smaller size than the dimension of skeleton meshes, and the other is that the skeleton tension is rather weak so that the formed vesicle can still move inward for NP internalization. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2158-3226 44800770 |
| Relation: | https://doaj.org/toc/2158-3226 |
| DOI: | 10.1063/1.4985052 |
| URL الوصول: | https://doaj.org/article/6bb6b72c19a44f448007706421597255 |
| رقم الأكسشن: | edsdoj.6bb6b72c19a44f448007706421597255 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 21583226 44800770 |
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| DOI: | 10.1063/1.4985052 |