دورية أكاديمية
EFFICIENCY OF RECOMBINANT TNF-BINDING PROTEIN FROM VARIOLA VIRUS IN A MODEL OF COLLAGEN-INDUCED ARTHRITIS
| العنوان: | EFFICIENCY OF RECOMBINANT TNF-BINDING PROTEIN FROM VARIOLA VIRUS IN A MODEL OF COLLAGEN-INDUCED ARTHRITIS |
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| المؤلفون: | D. D. Tsyrendorzhiev, S. V. Sennikov, I. A. Orlovskaya, I. P. Gileva, I. A. Ryazankin, L. B. Toporkova, V. V. Kurilin, Yu. A. Lopatnikova, A. A. Grydina, S. N. Schelkunov |
| المصدر: | Медицинская иммунология, Vol 15, Iss 6, Pp 513-524 (2014) |
| بيانات النشر: | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | tumor necrosis factor, collagen, variola virus, leukocytes, rheumatoid arthritis, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | Abstract. This paper presents the results of the research on the effectiveness of recombinant TNF-binding protein of variola virus (VARV-CrmB) in a model of collagen-induced arthritis (CIA) in mice (CBAxC57Bl6) F1. The introduction of VARV-CrmB and polyclonal antibody to recombinant mouse TNF (poly-AbMuTNF) led to an improvement of clinical manifestations of CIA by reducing the swelling and increasing the mobility of mice limbs. The introduction of VARV-CrmB and poly-AbMuTNF reduced the number of neutrophilic granulocytes and granulocytic precursors. The introduction of VARV-CrmB and poly-AbMuTNF into mice decreased collagenolysis in the blood serum and the content of glycosaminoglycans at the early stages of experimentation. Treatment with VARV-CrmB and poly-AbMuTNF of mice with CIA significantly decreased the chemiluminescence response of blood leukocytes. VARV-CrmB exerted more pronounced inhibitory effect on the production of reactive oxygen metabolites by blood leukocytes of mice with CIA than poly-AbMuTNF. Improvement of clinical condition of the mice with CIA has a more prolonged effect following introduction of the VARV-CrmB than after injection of poly-AbMuTNF. The results suggest the recombinant viral protein VARVCrmB to be a new potential TNF-antagonist. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1563-0625 2313-741X |
| Relation: | https://www.mimmun.ru/mimmun/article/view/675; https://doaj.org/toc/1563-0625; https://doaj.org/toc/2313-741X |
| DOI: | 10.15789/1563-0625-2013-6-513-524 |
| URL الوصول: | https://doaj.org/article/6bd0fc6fdfea43959facbd28c55ebf8b |
| رقم الأكسشن: | edsdoj.6bd0fc6fdfea43959facbd28c55ebf8b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15630625 2313741X |
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| DOI: | 10.15789/1563-0625-2013-6-513-524 |