دورية أكاديمية
Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice
| العنوان: | Effects of a Combination of Thyme and Oregano Essential Oils on TNBS-Induced Colitis in Mice |
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| المؤلفون: | Alexandra Bukovská, Štefan Cikoš, Štefan Juhás, Gabriela Il’ková, Pavol Rehák, Juraj Koppel |
| المصدر: | Mediators of Inflammation, Vol 2007 (2007) |
| بيانات النشر: | Wiley, 2007. |
| سنة النشر: | 2007 |
| المجموعة: | LCC:Pathology |
| مصطلحات موضوعية: | Pathology, RB1-214 |
| الوصف: | We examined the anti-inflammatory effects of the combination of thyme and oregano essential oil dietary administered at three concentrations (0.4% thyme and 0.2% oregano oils; 0.2% thyme and 0.1% oregano oils; 0.1% thyme and 0.05% oregano oils) on mice with TNBS-induced colitis. Treatment of colitic animals with the essential oils decreased the mRNA levels of pro-inflammatory cytokines IL-1β, IL-6, GM-CSF, and TNFα, especially after application of the medium dose. The medium dose of the essential oils significantly lowered the amount of IL-1β and IL-6 proteins too. Moreover, administration of the medium dose decreased the mortality rate, accelerated the body weight gain recovery, and reduced the macroscopic damage of the colonic tissue. Our results indicate that combined treatment with appropriate concentrations of thyme and oregano essential oils can reduce the production of proinflammatory cytokines, and thereby attenuate TNBS-induced colitis in mice. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0962-9351 1466-1861 |
| Relation: | https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861 |
| DOI: | 10.1155/2007/23296 |
| URL الوصول: | https://doaj.org/article/c6bfac08b8bf472892ff729d841ab061 |
| رقم الأكسشن: | edsdoj.6bfac08b8bf472892ff729d841ab061 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09629351 14661861 |
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| DOI: | 10.1155/2007/23296 |