دورية أكاديمية
A retrospective study of Parkinson's disease in Southwest China 2021–2024: An age-based approach
| العنوان: | A retrospective study of Parkinson's disease in Southwest China 2021–2024: An age-based approach |
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| المؤلفون: | Canrong Chen, Ding Zhang, Feiyu Chen, Donglin Wu, Wei Chen, Hongling Qin, Yueqiang Hu |
| المصدر: | Experimental Gerontology, Vol 195, Iss , Pp 112532- (2024) |
| بيانات النشر: | Elsevier, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | Parkinson's disease, N-HDL-C, Apo-B, Hs-CRP, Vitamin B12, Medicine, Biology (General), QH301-705.5 |
| الوصف: | Background: Globally, Parkinson's disease (PD) is one of the common neurodegenerative diseases in the elderly with increasing morbidity and disability, and its clinical pathogenesis is not clear. Objective: To compare the differences in disease severity and blood biomarkers levels and their correlation between patients with early-onset Parkinson's disease (EOPD) and late-onset Parkinson's disease (LOPD). Methods: A total of 342 patients diagnosed with PD were retrospectively collected. PD patients were categorized into EOPD (24 patients) and LOPD (318 patients) according to the age of onset of the disease. The Hoehn-Yahr (HY) staging was used to assess the severity of the disease in PD patients. Subjective rating scales such as the Mini-mental State Examination (MMSE) were used to assess the motor and non-motor functions of the patients. The differences of objective blood biomarkers such as triglyceride (TG) between the two groups were investigated. The correlation between them and PD was explored by logistic analysis. Results: Percentage of EOPD group with HY staged as intermediate to late and Scales for Outcomes in Parkinson's Disease-Autonomic (SCOPA-AUT), Movement Disorder Society-Unified Parkinson's disease Rating Scale-III (MDS-UPDRS-III), Montreal Cognitive Assessment (MoCA) score and TG, non-high-density lipoprotein-cholesterol (N-HDL-C), homocysteine (HCY), apolipoprotein B (Apo-B), free triiodothyronine (FT3), free thyroxine (FT4), high-sensitivity C-reactive protein (hs-CRP) levels were lower than those in the LOPD group (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1873-6815 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0531556524001748; https://doaj.org/toc/1873-6815 |
| DOI: | 10.1016/j.exger.2024.112532 |
| URL الوصول: | https://doaj.org/article/6c5d5d70820f4419a1fc1ba6fb6b3a40 |
| رقم الأكسشن: | edsdoj.6c5d5d70820f4419a1fc1ba6fb6b3a40 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 18736815 |
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| DOI: | 10.1016/j.exger.2024.112532 |