دورية أكاديمية
Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies
| العنوان: | Tasks and Experiences of the Prospective, Longitudinal, Multicenter MoMar (Molecular Markers) Study for the Early Detection of Mesothelioma in Individuals Formerly Exposed to Asbestos Using Liquid Biopsies |
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| المؤلفون: | Daniel Gilbert Weber, Swaantje Casjens, Katharina Wichert, Martin Lehnert, Dirk Taeger, Hans-Peter Rihs, Thomas Brüning, Georg Johnen, the MoMar Study Group |
| المصدر: | Cancers, Vol 15, Iss 24, p 5896 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | asbestos, biomarker, blood-based, calretinin, cancer, cohort, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Mesothelioma is an aggressive cancer, strongly associated with prior exposure to asbestos. Commonly, tumors are detected at late stages of the disease. Detection at early stages might be meaningful, because therapies might be more effective when the tumor burden is relatively low and the tumor has not spread to distant sites. Circulating biomarkers in blood might be a promising tool to improve the early detection of mesothelioma, but for screening in asymptomatic subjects, candidate biomarkers need to be validated in appropriate studies. This study was conducted to assess the performance of biomarkers in liquid biopsies to detect mesothelioma at early stages. Over a period of 10 years, 2769 volunteers formerly exposed to asbestos were annually examined and liquid biopsies were collected. A follow-up was completed 17 months after the last blood collection. The article provides a detailed overview of our lessons learned and experiences of conducting a prospective, longitudinal, multicenter study. The existing cohort of individuals at risk is highly suitable for the validation of blood-based biomarkers for the early detection of mesothelioma as well as lung cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 15245896 2072-6694 |
| Relation: | https://www.mdpi.com/2072-6694/15/24/5896; https://doaj.org/toc/2072-6694 |
| DOI: | 10.3390/cancers15245896 |
| URL الوصول: | https://doaj.org/article/6c6210d648324ea3bbf66ad0da380b7c |
| رقم الأكسشن: | edsdoj.6c6210d648324ea3bbf66ad0da380b7c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 15245896 20726694 |
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| DOI: | 10.3390/cancers15245896 |