دورية أكاديمية
Serum proteome profiles in cats with chronic enteropathies
العنوان: | Serum proteome profiles in cats with chronic enteropathies |
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المؤلفون: | Jane Yu, Lara Boland, Melissa Catt, Leah Puk, Nadia Wong, Mark Krockenberger, Peter Bennett, Craig Ruaux, Valerie C. Wasinger |
المصدر: | Journal of Veterinary Internal Medicine, Vol 37, Iss 4, Pp 1358-1367 (2023) |
بيانات النشر: | Wiley, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Veterinary medicine |
مصطلحات موضوعية: | alimentary small cell lymphoma, biomarkers, chronic enteropathies, low‐grade alimentary lymphoma, proteins, proteomics, Veterinary medicine, SF600-1100 |
الوصف: | Abstract Background Serum protein biomarkers are used to diagnose, monitor treatment response, and to differentiate various forms of chronic enteropathies (CE) in humans. The utility of liquid biopsy proteomic approaches has not been examined in cats. Hypothesis/Objectives To explore the serum proteome in cats to identify markers differentiating healthy cats from cats with CE. Animals Ten cats with CE with signs of gastrointestinal disease of at least 3 weeks duration, and biopsy‐confirmed diagnoses, with or without treatment and 19 healthy cats were included. Methods Cross‐sectional, multicenter, exploratory study with cases recruited from 3 veterinary hospitals between May 2019 and November 2020. Serum samples were analyzed and evaluated using mass spectrometry‐based proteomic techniques. Results Twenty‐six proteins were significantly (P 50‐fold increase in abundance in cats with CE (P |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1939-1676 0891-6640 |
Relation: | https://doaj.org/toc/0891-6640; https://doaj.org/toc/1939-1676 |
DOI: | 10.1111/jvim.16743 |
URL الوصول: | https://doaj.org/article/6ca08491f5fe442994dba21536c55856 |
رقم الأكسشن: | edsdoj.6ca08491f5fe442994dba21536c55856 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 19391676 08916640 |
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DOI: | 10.1111/jvim.16743 |