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Serum proteome profiles in cats with chronic enteropathies

التفاصيل البيبلوغرافية
العنوان: Serum proteome profiles in cats with chronic enteropathies
المؤلفون: Jane Yu, Lara Boland, Melissa Catt, Leah Puk, Nadia Wong, Mark Krockenberger, Peter Bennett, Craig Ruaux, Valerie C. Wasinger
المصدر: Journal of Veterinary Internal Medicine, Vol 37, Iss 4, Pp 1358-1367 (2023)
بيانات النشر: Wiley, 2023.
سنة النشر: 2023
المجموعة: LCC:Veterinary medicine
مصطلحات موضوعية: alimentary small cell lymphoma, biomarkers, chronic enteropathies, low‐grade alimentary lymphoma, proteins, proteomics, Veterinary medicine, SF600-1100
الوصف: Abstract Background Serum protein biomarkers are used to diagnose, monitor treatment response, and to differentiate various forms of chronic enteropathies (CE) in humans. The utility of liquid biopsy proteomic approaches has not been examined in cats. Hypothesis/Objectives To explore the serum proteome in cats to identify markers differentiating healthy cats from cats with CE. Animals Ten cats with CE with signs of gastrointestinal disease of at least 3 weeks duration, and biopsy‐confirmed diagnoses, with or without treatment and 19 healthy cats were included. Methods Cross‐sectional, multicenter, exploratory study with cases recruited from 3 veterinary hospitals between May 2019 and November 2020. Serum samples were analyzed and evaluated using mass spectrometry‐based proteomic techniques. Results Twenty‐six proteins were significantly (P 50‐fold increase in abundance in cats with CE (P
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1939-1676
0891-6640
Relation: https://doaj.org/toc/0891-6640; https://doaj.org/toc/1939-1676
DOI: 10.1111/jvim.16743
URL الوصول: https://doaj.org/article/6ca08491f5fe442994dba21536c55856
رقم الأكسشن: edsdoj.6ca08491f5fe442994dba21536c55856
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19391676
08916640
DOI:10.1111/jvim.16743