دورية أكاديمية
Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury
| العنوان: | Neurod4 converts endogenous neural stem cells to neurons with synaptic formation after spinal cord injury |
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| المؤلفون: | Toshiki Fukuoka, Akira Kato, Masaki Hirano, Fumiharu Ohka, Kosuke Aoki, Takayuki Awaya, Alimu Adilijiang, Maeda Sachi, Kuniaki Tanahashi, Junya Yamaguchi, Kazuya Motomura, Hiroyuki Shimizu, Yoshitaka Nagashima, Ryo Ando, Toshihiko Wakabayashi, Dasfne Lee-Liu, Juan Larrain, Yusuke Nishimura, Atsushi Natsume |
| المصدر: | iScience, Vol 24, Iss 2, Pp 102074- (2021) |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | Biological Sciences, Neuroscience, Behavioral Neuroscience, Cellular Neuroscience, Science |
| الوصف: | Summary: The transcriptome analysis of injured Xenopus laevis tadpole and mice suggested that Neurod4L.S., a basic-helix-loop-helix transcription factor, was the most promising transcription factor to exert neuroregeneration after spinal cord injury (SCI) in mammals. We generated a pseudotyped retroviral vector with the neurotropic lymphocytic choriomeningitis virus (LCMV) envelope to deliver murine Neurod4 to mice undergoing SCI. SCI induced ependymal cells to neural stem cells (NSCs) in the central canal. The LCMV envelope-based pseudotypedvector preferentially introduced Neurod4 into activated NSCs, which converted to neurons with axonal regrowth and suppressed the scar-forming glial lineage. Neurod4-induced inhibitory neurons predominantly projected to the subsynaptic domains of motor neurons at the epicenter, and Neurod4-induced excitatory neurons predominantly projected to subsynaptic domains of motor neurons caudal to the injury site suggesting the formation of functional synapses. Thus, Neurod4 is a potential therapeutic factor that can improve anatomical and functional recovery after SCI. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2589-0042 81827083 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2589004221000420; https://doaj.org/toc/2589-0042 |
| DOI: | 10.1016/j.isci.2021.102074 |
| URL الوصول: | https://doaj.org/article/6cd8182708364d5086ad0510d3d4d533 |
| رقم الأكسشن: | edsdoj.6cd8182708364d5086ad0510d3d4d533 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25890042 81827083 |
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| DOI: | 10.1016/j.isci.2021.102074 |