دورية أكاديمية
Glucose Transporter 1 deficiency and associated conditions in children
| العنوان: | Glucose Transporter 1 deficiency and associated conditions in children |
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| المؤلفون: | R. G. Gamirova, Z. Afawi, R. R. Gamirova, E. A. Gorobets, V. F. Prusakov, S. Ya. Volgina |
| المصدر: | Rossijskij Vestnik Perinatologii i Pediatrii, Vol 64, Iss 5, Pp 155-158 (2019) |
| بيانات النشر: | Ltd. “The National Academy of Pediatric Science and Innovation”, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Pediatrics |
| مصطلحات موضوعية: | дети, дефицит транспортера глюкозы i типа, glut1, ген slc2a1, эпилепсия, когнитивные нарушения, кетогенная диета, Pediatrics, RJ1-570 |
| الوصف: | The article reviews literature devoted to the glucose transporter type I deficiency syndrome (synonyms: GLUT1 deficiency syndrome, de Vivo disease), that is a genetically determined disease caused by pathogenic variants of the SLC2A1 gene. The insufficiency of this protein leads to the disruption of glucose delivery to the brain through the blood-brain barrier. Clinically, the syndrome is manifested by epileptic seizures (mainly as absences or myoclonic seizures), various motor disorders and psychomotor retardation starting from the early age.Early diagnosis (including molecular genetic analysis of the SLC2A1 gene) enables us to start treatment and prevent progression of the symptoms, and to provide the family with genetic consultation on the prognosis and risks for the next generations. Ketogenic diet is an effective treatment option for this pathological condition, it can lead to a regression of the clinical manifestations, especially on the early stage. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1027-4065 2500-2228 |
| Relation: | https://www.ped-perinatology.ru/jour/article/view/984; https://doaj.org/toc/1027-4065; https://doaj.org/toc/2500-2228 |
| DOI: | 10.21508/1027-4065-2019-64-5-155-158 |
| URL الوصول: | https://doaj.org/article/6d09f09de6ae4841bf0038a4f4b36f4f |
| رقم الأكسشن: | edsdoj.6d09f09de6ae4841bf0038a4f4b36f4f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 10274065 25002228 |
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| DOI: | 10.21508/1027-4065-2019-64-5-155-158 |