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Strain-specific Plasmodium falciparum growth inhibition among Malian children immunized with a blood-stage malaria vaccine.

التفاصيل البيبلوغرافية
العنوان: Strain-specific Plasmodium falciparum growth inhibition among Malian children immunized with a blood-stage malaria vaccine.
المؤلفون: Matthew B Laurens, Bourema Kouriba, Elke Bergmann-Leitner, Evelina Angov, Drissa Coulibaly, Issa Diarra, Modibo Daou, Amadou Niangaly, William C Blackwelder, Yukun Wu, Joe Cohen, W Ripley Ballou, Johan Vekemans, David E Lanar, Sheetij Dutta, Carter Diggs, Lorraine Soisson, D Gray Heppner, Ogobara K Doumbo, Christopher V Plowe, Mahamadou A Thera
المصدر: PLoS ONE, Vol 12, Iss 3, p e0173294 (2017)
بيانات النشر: Public Library of Science (PLoS), 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: The blood-stage malaria vaccine FMP2.1/AS02A, comprised of recombinant Plasmodium falciparum apical membrane antigen 1 (AMA1) and the adjuvant system AS02A, had strain-specific efficacy against clinical malaria caused by P. falciparum with the vaccine strain 3D7 AMA1 sequence. To evaluate a potential correlate of protection, we measured the ability of participant sera to inhibit growth of 3D7 and FVO strains in vitro using high-throughput growth inhibition assay (GIA) testing. Sera from 400 children randomized to receive either malaria vaccine or a control rabies vaccine were assessed at baseline and over two annual malaria transmission seasons after immunization. Baseline GIA against vaccine strain 3D7 and FVO strain was similar in both groups, but more children in the malaria vaccine group than in the control group had 3D7 and FVO GIA activity ≥15% 30 days after the last vaccination (day 90) (49% vs. 16%, p
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC5345808?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0173294
URL الوصول: https://doaj.org/article/6d13068d77704a0982ced7606e6c4c8b
رقم الأكسشن: edsdoj.6d13068d77704a0982ced7606e6c4c8b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0173294