دورية أكاديمية
The role of podocytes dysfunction in chronic glomerulonephritis progression
| العنوان: | The role of podocytes dysfunction in chronic glomerulonephritis progression |
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| المؤلفون: | N V Chebotareva, I N Bobkova, L V Lysenko |
| المصدر: | Терапевтический архив, Vol 90, Iss 6, Pp 92-97 (2018) |
| بيانات النشر: | "Consilium Medicum" Publishing house, 2018. |
| سنة النشر: | 2018 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | podocyturia, nephrinuria, podocyte dysfunction, podocytopenia, chronic glomerulonephritis, Medicine |
| الوصف: | In the review, the mechanisms of podocytes damage underlying the development of proteinuria and progression of glomerulosclerosis in chronic glomerulonephritis are discussed in detail. The results of experimental and clinical studies are presented. Under the different immune and non-immune factors the podocytes form a stereotyped response to damage consisting in the reorganization of the actin cytoskeleton, foot process effacement, the detachment of podocytes from the glomerular basement membrane, and the appearance of specific podocyte proteins and whole cells (podocyturia) in the urine. Massive podocyturia in a limited proliferative capacity of podocytes leads to reduce their total count in the glomerulus (podocytopenia) and the development of glomerulosclerosis. The authors describe the line of markers of the podocyte injury and invasive and non-invasive methods of their assessment. In addition, the relationship of podocyturia level with proteinuria and renal dysfunction are discussed, the prospects of assessment the podocyte proteins in urine for assessing of glomerular damage severity and glomerulosclerosis risk are examined. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 0040-3660 2309-5342 |
| Relation: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32795/pdf; https://doaj.org/toc/0040-3660; https://doaj.org/toc/2309-5342 |
| DOI: | 10.26442/terarkh201890692-97 |
| URL الوصول: | https://doaj.org/article/6d38e63a58ec432781034b0257aca72f |
| رقم الأكسشن: | edsdoj.6d38e63a58ec432781034b0257aca72f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 00403660 23095342 |
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| DOI: | 10.26442/terarkh201890692-97 |