دورية أكاديمية
A Pleiotropic Role of the Hepatitis B Virus Core Protein in Hepatocarcinogenesis
العنوان: | A Pleiotropic Role of the Hepatitis B Virus Core Protein in Hepatocarcinogenesis |
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المؤلفون: | Caroline Lefeuvre, Hélène Le Guillou-Guillemette, Alexandra Ducancelle |
المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 24, p 13651 (2021) |
بيانات النشر: | MDPI AG, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Biology (General) LCC:Chemistry |
مصطلحات موضوعية: | hepatitis B virus, hepatitis B virus core protein, hepatocellular carcinoma, hepatocarcinogenesis, Biology (General), QH301-705.5, Chemistry, QD1-999 |
الوصف: | Chronic hepatitis B virus (HBV) infection is one of the most common factors associated with hepatocellular carcinoma (HCC), which is the sixth most prevalent cancer among all cancers worldwide. However, the pathogenesis of HBV-mediated hepatocarcinogenesis is unclear. Evidence currently available suggests that the HBV core protein (HBc) plays a potential role in the development of HCC, such as the HBV X protein. The core protein, which is the structural component of the viral nucleocapsid, contributes to almost every stage of the HBV life cycle and occupies diverse roles in HBV replication and pathogenesis. Recent studies have shown that HBc was able to disrupt various pathways involved in liver carcinogenesis: the signaling pathways implicated in migration and proliferation of hepatoma cells, apoptosis pathways, and cell metabolic pathways inducing the development of HCC; and the immune system, through the expression and production of proinflammatory cytokines. In addition, HBc can modulate normal functions of hepatocytes through disrupting human host gene expression by binding to promoter regions. This HBV protein also promotes HCC metastasis through epigenetic alterations, such as micro-RNA. This review focuses on the molecular pathogenesis of the HBc protein in HBV-induced HCC. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1422-0067 1661-6596 |
Relation: | https://www.mdpi.com/1422-0067/22/24/13651; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
DOI: | 10.3390/ijms222413651 |
URL الوصول: | https://doaj.org/article/6d65d5f332d14a4198240443e7cb7b32 |
رقم الأكسشن: | edsdoj.6d65d5f332d14a4198240443e7cb7b32 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 14220067 16616596 |
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DOI: | 10.3390/ijms222413651 |