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Estrogen enhances female small intestine epithelial organoid regeneration

التفاصيل البيبلوغرافية
العنوان: Estrogen enhances female small intestine epithelial organoid regeneration
المؤلفون: Greg S. Lee, Alexander S. Cody, Kent C. Johnson, Helong Zhao, Shannon J. Odelberg, Dean Y. Li, Weiquan Zhu
المصدر: Journal of Bio-X Research, Vol 2, Iss 1, Pp 9-15 (2019)
بيانات النشر: Wolters Kluwer Health, 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
LCC:Biology (General)
مصطلحات موضوعية: Medicine, Biology (General), QH301-705.5
الوصف: Abstract. Promoting intestinal epithelial regeneration remains a major medical challenge. Female patients taking nonsteroidal anti-inflammatory drugs are less likely to have upper gastrointestinal bleeding and ulcers than males. Using a nonsteroidal anti-inflammatory drug-induced intestinal damage mouse model, we verified that female mice recover faster than males following acute intestinal insult. Using ex vivo intestinal organoid cultures, we showed that estrogen is necessary and sufficient in enhancing the female organoid formation from breached isolated crypts via the estrogen receptor β receptor. Thus, estrogen promotes female intestinal epithelial organoid regeneration to lower the incidence of intestinal bleeding and ulceration. Animal studies were approved by University of Utah IACUC under protocol number 16-05012 and 18-02010.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2096-5672
2577-3585
00000000
Relation: http://journals.lww.com/10.1097/JBR.0000000000000029; https://doaj.org/toc/2096-5672; https://doaj.org/toc/2577-3585
DOI: 10.1097/JBR.0000000000000029
URL الوصول: https://doaj.org/article/6d76443966c6418db571c74d67a8d5ef
رقم الأكسشن: edsdoj.6d76443966c6418db571c74d67a8d5ef
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20965672
25773585
00000000
DOI:10.1097/JBR.0000000000000029