دورية أكاديمية
A Study of the Resistance of Hu Sheep Lambs to Escherichia coli F17 Based on Whole Genome Sequencing
| العنوان: | A Study of the Resistance of Hu Sheep Lambs to Escherichia coli F17 Based on Whole Genome Sequencing |
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| المؤلفون: | Yanjun Duan, Pengwei Su, Yifei Gu, Xiaoyang Lv, Xiukai Cao, Shanhe Wang, Zehu Yuan, Wei Sun |
| المصدر: | Animals, Vol 14, Iss 1, p 161 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Veterinary medicine LCC:Zoology |
| مصطلحات موضوعية: | whole genome sequencing, Escherichia coli F17, Hu sheep lambs, antagonistic phenotype, susceptible phenotype, Veterinary medicine, SF600-1100, Zoology, QL1-991 |
| الوصف: | This study aims to analyze the whole genome sequencing of E. coli F17 in antagonistic and susceptible Hu sheep lambs. The objective is to investigate the critical mutation loci in sheep and understand the genetic mechanism of sheep resistance to E. coli F17 at the genome level. Antagonist and susceptible venous blood samples were collected from Hu sheep lambs for whole genome sequencing and whole genome association analysis. A total of 466 genes with significant SNPs (p < 1.0 × 10−3) were found. GO and KEGG enrichment analysis and protein interaction network analysis were performed on these genes, and preliminary investigations showed that SNPs on CTNNB1, CDH8, APOD, HCLS1, Tet2, MTSS1 and YAP1 genes may be associated with the antagonism and susceptibility of Hu sheep lambs to E. coli F17. There are still some shortcomings that have not been explored via in vivo and in vitro functional experiments of the candidate genes, which will be our next research work. This study provides genetic loci and candidate genes for resistance of Hu sheep lambs to E. coli F17 infection, and provides a genetic basis for breeding disease-resistant sheep. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2076-2615 |
| Relation: | https://www.mdpi.com/2076-2615/14/1/161; https://doaj.org/toc/2076-2615 |
| DOI: | 10.3390/ani14010161 |
| URL الوصول: | https://doaj.org/article/e6dca8e443d64484813a7b27aa209ddc |
| رقم الأكسشن: | edsdoj.6dca8e443d64484813a7b27aa209ddc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20762615 |
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| DOI: | 10.3390/ani14010161 |