دورية أكاديمية
أعرض في EDS

An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma

التفاصيل البيبلوغرافية
العنوان: An inflammatory-CCRK circuitry drives mTORC1-dependent metabolic and immunosuppressive reprogramming in obesity-associated hepatocellular carcinoma
المؤلفون: Hanyong Sun, Weiqin Yang, Yuan Tian, Xuezhen Zeng, Jingying Zhou, Myth T. S. Mok, Wenshu Tang, Yu Feng, Liangliang Xu, Anthony W. H. Chan, Joanna H. Tong, Yue-Sun Cheung, Paul B. S. Lai, Hector K. S. Wang, Shun-Wa Tsang, King-Lau Chow, Mengying Hu, Rihe Liu, Leaf Huang, Bing Yang, Pengyuan Yang, Ka-Fai To, Joseph J. Y. Sung, Grace L. H. Wong, Vincent W. S. Wong, Alfred S. L. Cheng
المصدر: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
بيانات النشر: Nature Portfolio, 2018.
سنة النشر: 2018
المجموعة: LCC:Science
مصطلحات موضوعية: Science
الوصف: Obesity increases the risk of hepatocellular carcinoma (HCC) especially in men. Here the authors find a potential mechanistic explanation by showing that, in mice, obesity-induced STAT3 cooperates with the androgen receptor to activate the mTORC pathway through up regulation of CCRK, resulting in hepatic steatosis worsening and HCC development via metabolic and immune reprogramming.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-1723
Relation: https://doaj.org/toc/2041-1723
DOI: 10.1038/s41467-018-07402-8
URL الوصول: https://doaj.org/article/6dd5d597aab145d5bf368e0227da0aaf
رقم الأكسشن: edsdoj.6dd5d597aab145d5bf368e0227da0aaf
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20411723
DOI:10.1038/s41467-018-07402-8