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The genetics of multiple sclerosis: review of current and emerging candidates

التفاصيل البيبلوغرافية
العنوان: The genetics of multiple sclerosis: review of current and emerging candidates
المؤلفون: Muñoz-Culla M, Irizar H, Otaegui D
المصدر: The Application of Clinical Genetics, Vol 2013, Iss default, Pp 63-73 (2013)
بيانات النشر: Dove Medical Press, 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine (General)
LCC:Genetics
مصطلحات موضوعية: Medicine (General), R5-920, Genetics, QH426-470
الوصف: Maider Muñoz-Culla,1,2 Haritz Irizar,1,2 David Otaegui1,2 1Multiple Sclerosis Unit, Instituto Biodonostia, San Sebastián, Spain; 2Red Española de Esclerosis Múltiple (REEM), Barcelona, Spain Abstract: Multiple sclerosis (MS) is a complex disease in which environmental, genetic, and epigenetic factors determine the risk of developing the disease. The human leukocyte antigen region is the strongest susceptibility locus linked to MS, but it does not explain the whole heritability of the disease. To find other non-human leukocyte antigen loci associated with the disease, high-throughput genotyping, sequencing, and gene-expression studies have been performed, producing a valuable quantity of information. An overview of the genomic and expression studies is provided in this review, as well as microRNA-expression studies, highlighting the importance of combining all the layers of information in order to elucidate the causes or pathological mechanisms occurring in the disease. Genetics in MS is a promising field that is presumably going to be very productive in the next decade understanding the cross talk between all the factors contributing to the development of MS. Keywords: multiple sclerosis, genetics, gene expression, microRNA
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1178-704X
Relation: http://www.dovepress.com/the-genetics-of-multiple-sclerosis-review-of-current-and-emerging-cand-a13947; https://doaj.org/toc/1178-704X
URL الوصول: https://doaj.org/article/c6ddfaba6fe143b99c89b5d0313b3e20
رقم الأكسشن: edsdoj.6ddfaba6fe143b99c89b5d0313b3e20
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:1178704X