دورية أكاديمية
Salsalate and/or metformin therapy confer beneficial metabolic effects in olanzapine treated female mice
| العنوان: | Salsalate and/or metformin therapy confer beneficial metabolic effects in olanzapine treated female mice |
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| المؤلفون: | Hesham Shamshoum, Kyle D. Medak, Greg L. McKie, Stewart Jeromson, Margaret K. Hahn, David C. Wright |
| المصدر: | Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115671- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Metformin, Salsalate, Antipsychotic, Mice, Obesity, Glucose, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Antipsychotic medications are used in the management of schizophrenia and a growing number of off-label conditions. While effective at reducing psychoses, these drugs possess noted metabolic side effects including weight gain, liver lipid accumulation and disturbances in glucose and lipid metabolism. To counter the side effects of antipsychotics standard of care has typically included metformin. Unfortunately, metformin does not protect against antipsychotic induced metabolic disturbances in all patients and thus additional treatment approaches are needed. One potential candidate could be salsalate, the prodrug of salicylate, which acts synergistically with metformin to improve indices of glucose and lipid metabolism in obese mice. The purpose of the current investigation was to compare the effects of salsalate, metformin and a combination of both drugs, on weight gain and indices of metabolic health in female mice treated with the antipsychotic, olanzapine. Herein we demonstrate that salsalate was equally as effective as metformin in protecting against olanzapine induced weight gain and liver lipid accumulation with no additional benefit of combining both drugs. Conversely, metformin treatment, either alone or in combination with salsalate, improved indices of glucose metabolism and increased energy expenditure in olanzapine treated mice. Collectively, our findings provide evidence that dual therapy with both metformin and salsalate could be an efficacious approach with which to dampen the metabolic consequences of antipsychotic medications. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0753-3322 28604652 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S0753332223014695; https://doaj.org/toc/0753-3322 |
| DOI: | 10.1016/j.biopha.2023.115671 |
| URL الوصول: | https://doaj.org/article/6de73a7a28604652ba7b642fa2ff7f7b |
| رقم الأكسشن: | edsdoj.6de73a7a28604652ba7b642fa2ff7f7b |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 07533322 28604652 |
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| DOI: | 10.1016/j.biopha.2023.115671 |