دورية أكاديمية
Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis.
العنوان: | Neuronal expression of glucosylceramide synthase in central nervous system regulates body weight and energy homeostasis. |
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المؤلفون: | Viola Nordström, Monja Willershäuser, Silke Herzer, Jan Rozman, Oliver von Bohlen Und Halbach, Sascha Meldner, Ulrike Rothermel, Sylvia Kaden, Fabian C Roth, Clemens Waldeck, Norbert Gretz, Martin Hrabě de Angelis, Andreas Draguhn, Martin Klingenspor, Hermann-Josef Gröne, Richard Jennemann |
المصدر: | PLoS Biology, Vol 11, Iss 3, p e1001506 (2013) |
بيانات النشر: | Public Library of Science (PLoS), 2013. |
سنة النشر: | 2013 |
المجموعة: | LCC:Biology (General) |
مصطلحات موضوعية: | Biology (General), QH301-705.5 |
الوصف: | Hypothalamic neurons are main regulators of energy homeostasis. Neuronal function essentially depends on plasma membrane-located gangliosides. The present work demonstrates that hypothalamic integration of metabolic signals requires neuronal expression of glucosylceramide synthase (GCS; UDP-glucose:ceramide glucosyltransferase). As a major mechanism of central nervous system (CNS) metabolic control, we demonstrate that GCS-derived gangliosides interacting with leptin receptors (ObR) in the neuronal membrane modulate leptin-stimulated formation of signaling metabolites in hypothalamic neurons. Furthermore, ganglioside-depleted hypothalamic neurons fail to adapt their activity (c-Fos) in response to alterations in peripheral energy signals. Consequently, mice with inducible forebrain neuron-specific deletion of the UDP-glucose:ceramide glucosyltransferase gene (Ugcg) display obesity, hypothermia, and lower sympathetic activity. Recombinant adeno-associated virus (rAAV)-mediated Ugcg delivery to the arcuate nucleus (Arc) significantly ameliorated obesity, specifying gangliosides as seminal components for hypothalamic regulation of body energy homeostasis. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1544-9173 1545-7885 |
Relation: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23554574/?tool=EBI; https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885 |
DOI: | 10.1371/journal.pbio.1001506 |
URL الوصول: | https://doaj.org/article/6df52cc8e3e74af38026d85d326f2919 |
رقم الأكسشن: | edsdoj.6df52cc8e3e74af38026d85d326f2919 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 15449173 15457885 |
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DOI: | 10.1371/journal.pbio.1001506 |