دورية أكاديمية

Correlation between sestrin2 expression and airway remodeling in COPD

التفاصيل البيبلوغرافية
العنوان: Correlation between sestrin2 expression and airway remodeling in COPD
المؤلفون: Da-Wei Zhang, Yuan-Yuan Wei, Shuang Ji, Guang-He Fei
المصدر: BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-10 (2020)
بيانات النشر: BMC, 2020.
سنة النشر: 2020
المجموعة: LCC:Diseases of the respiratory system
مصطلحات موضوعية: Sestrin2, Airway remodeling, COPD, Matrix metalloproteinase 9, Quantitative computed tomography, Diseases of the respiratory system, RC705-779
الوصف: Abstract Background Airway remodeling is a major pathological characteristic of chronic obstructive pulmonary disease (COPD), and has been shown to be associated with oxidative stress. Sestrin2 has recently drawn attention as an important antioxidant protein. However, the underlying correlation between sestrin2 and airway remodeling in COPD has yet to be clarified. Methods A total of 124 subjects were enrolled in this study, including 62 control subjects and 62 COPD patients. The pathological changes in airway tissues were assessed by different staining methods. The expression of sestrin2 and matrix metalloproteinase 9 (MMP9) in airway tissues was monitored by immunohistochemistry. Enzyme-linked immunosorbent assays (ELISAs) were used to detect the serum concentrations of sestrin2 and MMP9. The airway parameters on computed tomography (CT) from all participants were measured for evaluating airway remodeling. The relationship between serum sestrin2 and MMP9 concentration and airway parameters in chest CT was also analyzed. Results In patients with COPD, staining of airway structures showed distinct pathological changes of remodeling, including cilia cluttered, subepithelial fibrosis, and reticular basement membrane (Rbm) fragmentation. Compared with control subjects, the expression of sestrin2 and MMP9 was significantly increased in both human airway tissues and serum. Typical imaging characteristics of airway remodeling and increased airway parameters were also found by chest CT. Additionally, serum sestrin2 concentration was positively correlated with serum MMP9 concentration and airway parameters in chest CT. Conclusion Increased expression of sestrin2 is related to airway remodeling in COPD. We demonstrated for the first time that sestrin2 may be a novel biomarker for airway remodeling in patients with COPD.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1471-2466
Relation: http://link.springer.com/article/10.1186/s12890-020-01329-x; https://doaj.org/toc/1471-2466
DOI: 10.1186/s12890-020-01329-x
URL الوصول: https://doaj.org/article/6e52085545874fa69f13a948fbe89311
رقم الأكسشن: edsdoj.6e52085545874fa69f13a948fbe89311
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14712466
DOI:10.1186/s12890-020-01329-x