دورية أكاديمية
Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness
العنوان: | Chronic Mild Hyperglycemia in GCK-MODY Patients Does Not Increase Carotid Intima-Media Thickness |
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المؤلفون: | Stepanka Pruhova, Petra Dusatkova, Pavel J. Kraml, Michal Kulich, Zdena Prochazkova, Jan Broz, Jaroslav Zikmund, Ondrej Cinek, Michal Andel, Oluf Pedersen, Torben Hansen, Jan Lebl |
المصدر: | International Journal of Endocrinology, Vol 2013 (2013) |
بيانات النشر: | Wiley, 2013. |
سنة النشر: | 2013 |
المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
مصطلحات موضوعية: | Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
الوصف: | Aim. GCK-MODY is an autosomal dominant form of diabetes caused by heterozygous mutations in the glucokinase gene leading to a lifelong mild hyperglycemia. The risk of macrovascular complications is considered low, but studies are limited. We, therefore, investigated the carotid intima-media thickness (CIMT) as an indicator of macrovascular complications in a group of patients with GCK-MODY. Methods. Twenty-seven GCK mutation carriers and 24 controls recruited among their first-degree relatives were compared, all aging over 35 years. The CIMT was tested using a high-resolution B-mode carotid ultrasonography. Medical history, anthropometry, and biochemical blood workup were obtained. Results. The mean CIMT was 0.707 ± 0.215 mm (mean ± SD) in GCK mutation carriers and 0.690 ± 0.180 mm in control individuals. When adjusted for age, gender, and family status, the estimated mean difference in CIMT between the two groups increased to 0.049 mm (P=0.19). No difference was detected for other characteristics, with the exception of fasting blood glucose (GCK-MODY 7.6 mmol/L ± 1.2 (136.4 mg/dL); controls 5.3 mmol/L ± 0.3 (95.4 mg/dL); P |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1687-8337 1687-8345 |
Relation: | https://doaj.org/toc/1687-8337; https://doaj.org/toc/1687-8345 |
DOI: | 10.1155/2013/718254 |
URL الوصول: | https://doaj.org/article/6e64715ebc0d4de5a9a37b9e9200fbca |
رقم الأكسشن: | edsdoj.6e64715ebc0d4de5a9a37b9e9200fbca |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 16878337 16878345 |
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DOI: | 10.1155/2013/718254 |