A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling

التفاصيل البيبلوغرافية
العنوان:	A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling
المؤلفون:	Alexandre Beautrait, Justine S. Paradis, Brandon Zimmerman, Jenna Giubilaro, Ljiljana Nikolajev, Sylvain Armando, Hiroyuki Kobayashi, Lama Yamani, Yoon Namkung, Franziska M. Heydenreich, Etienne Khoury, Martin Audet, Philippe P. Roux, Dmitry B. Veprintsev, Stéphane A. Laporte, Michel Bouvier
المصدر:	Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
بيانات النشر:	Nature Portfolio, 2017.
سنة النشر:	2017
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Beta-arrestins play central roles in the mechanisms regulating GPCR signalling and trafficking. Here the authors identify a selective inhibitor of the interaction between β-arrestin and the β2-adaptin subunit of the clathrin adaptor protein AP-2, which they use to dissect the role of the β-arrestin/β2-adaptin interaction in GPCR signalling.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/ncomms15054
URL الوصول:	https://doaj.org/article/6eba6ba8e03a459fb317fb0b5ab08460
رقم الأكسشن:	edsdoj.6eba6ba8e03a459fb317fb0b5ab08460
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/ncomms15054