Abstract Introduction Pregabalin is a widely prescribed medication for various medical conditions, including neuropathic pain and anxiety disorders. Recently, several studies have shown an increase in the recreational use of pregabalin, particularly among vulnerable populations, such as the migrant population. Methods The authors aim to present two case reports of pregabalin use disorder observed among migrants residing in a temporary detention center for undocumented migrants in Portugal, and to conduct a non-systematic review of the literature on the potential abuse of pregabalin. Results A growing body of research suggests an increasing global trend toward the inappropriate use linked with gabapentinoid medications, particularly pregabalin. The occurrence of euphoria, sedation, and dissociation at higher doses appears to be related to its abuse potential. Studies show that pregabalin abuse occurs particularly in patients with substance use disorders and in vulnerable populations such as migrants. Conclusion The migrant population appears to be particularly vulnerable to pregabalin abuse. Healthcare professionals should be aware of this emerging problem, especially if they work directly with this population. Prescribing should be done with caution, and when suspected, screening for abuse should be conducted.
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