دورية أكاديمية
Cigarette smoking induces the activation of RIP2/caspase-12/NF-κB axis in oral squamous cell carcinoma
| العنوان: | Cigarette smoking induces the activation of RIP2/caspase-12/NF-κB axis in oral squamous cell carcinoma |
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| المؤلفون: | Yajie Qian, Wenmei Wang, Deyan Chen, Yanan Zhu, Yong Wang, Xiang Wang |
| المصدر: | PeerJ, Vol 10, p e14330 (2022) |
| بيانات النشر: | PeerJ Inc., 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Biology (General) |
| مصطلحات موضوعية: | Cigarette smoking, Oral squamous cell carcinoma, RIP2, Caspase-12, NF-κB, Medicine, Biology (General), QH301-705.5 |
| الوصف: | Cigarette smoking is one of the major risk factors for the occurrence and progression of oral squamous cell carcinoma (OSCC). Receptor-interacting protein 2 (RIP2) has been involved in mucosal immunity and homeostasis via a positive regulation of nuclear factor κB (NF-κB) transcription factor activity. Caspase-12 can bind to RIP2 and dampen mucosal immunity. However, the roles of RIP2/NF-κB and caspase-12 in OSCC induced by cigarette smoking remain unknown. Herein, we investigated the effects of cigarette smoking on the RIP2/NF-κB and caspase-12 in human OSCC tissues and OSCC cell lines (HSC-3). We first observed that RIP2 mediated NF-κB activation and caspase-12 upregulation in OSCC patients with cigarette smoking and cigarette smoke extract (CSE)-treated HSC-3 cells, respectively. Moreover, we confirmed that the downregulation of RIP2 by siRNA resulted in the reduction of caspase-12 expression and NF-κB activity in the presence of CSE treatment in vitro. In summary, our results indicated that cigarette smoking induced the activation of the RIP2/caspase-12/NF-κB axis and it played an important role in the development of OSCC. The RIP2/caspase-12/NF-κB axis could be a target for OSCC prevention and treatment in the future. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2167-8359 |
| Relation: | https://peerj.com/articles/14330.pdf; https://peerj.com/articles/14330/; https://doaj.org/toc/2167-8359 |
| DOI: | 10.7717/peerj.14330 |
| URL الوصول: | https://doaj.org/article/6ef42e59e92d4bdea337915568fca3a2 |
| رقم الأكسشن: | edsdoj.6ef42e59e92d4bdea337915568fca3a2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21678359 |
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| DOI: | 10.7717/peerj.14330 |