دورية أكاديمية
Treatment of multiple myeloma: What is the impact on T-cell function?
| العنوان: | Treatment of multiple myeloma: What is the impact on T-cell function? |
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| المؤلفون: | Chenggong Li, Xindi Wang, Jia Xu, Jiachen Liu, Heng Mei |
| المصدر: | Therapeutic Advances in Hematology, Vol 15 (2024) |
| بيانات النشر: | SAGE Publishing, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | Treatment of multiple myeloma (MM) has evolved remarkably over the past few decades. Autologous stem cell transplantation, as well as proteasome inhibitors, immunomodulatory drugs, and monoclonal antibodies, has substantially improved the prognosis of patients with MM. Novel therapies, including chimeric antigen receptor-T cells, bispecific T-cell engagers, antibody-drug conjugates, histone deacetylase inhibitors, and nuclear export inhibitors, have provided more options. However, MM remains incurable. T cells are the principal weapons of antitumor immunity, but T cells display a broad spectrum of dysfunctional states during MM. The promising clinical results of T-cell-directed immunotherapies emphasize the significance of enhancing T-cell function in antimyeloma treatment. This review summarizes the potential effects of these antimyeloma agents on T-cell function and discusses possible optimized strategies for MM management by boosting T-cell immunity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2040-6215 20406207 |
| Relation: | https://doaj.org/toc/2040-6215 |
| DOI: | 10.1177/20406207241245194 |
| URL الوصول: | https://doaj.org/article/6f4170ec1e0945cfb4cfe86124b8e97a |
| رقم الأكسشن: | edsdoj.6f4170ec1e0945cfb4cfe86124b8e97a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20406215 20406207 |
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| DOI: | 10.1177/20406207241245194 |