دورية أكاديمية
The multivariate analysis of results of bedaquiline use in the therapy of MDR/XDR pulmonary tuberculosis
| العنوان: | The multivariate analysis of results of bedaquiline use in the therapy of MDR/XDR pulmonary tuberculosis |
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| المؤلفون: | N. V. Stavitskaya, I. G. Felker, E. M. Zhukova, А. I. Tlif, N. P. Doktorova, D. А. Kudlay |
| المصدر: | Туберкулез и болезни лёгких, Vol 98, Iss 7, Pp 56-62 (2020) |
| بيانات النشر: | New Terra Publishing House, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | туберкулез легких, множественная лекарственная устойчивость, многофакторный анализ, лечение, бедаквилин, химиотерапия, Diseases of the respiratory system, RC705-779 |
| الوصف: | The objective of the study: to perform the multivariate analysis of treatment outcomes in patients with multiple/extensive drug resistant tuberculosis (MDR/XDR TB), including those with HIV infection, whose chemotherapy regimens included bedaquiline. Subjects and methods: 70 patients with MDR/XDR TB were enrolled in the retrospective two-center study, the multivariate analysis of treatment outcomes with bedaquiline-containing regimen was carried out. Results: the performed multivariate analysis demonstrated high efficacy and good tolerability of bedaquiline-containing regimens for MDR/XDR TB treatment even despite the continuous ineffective treatment of patients in the past. The prolonged intake of bedaquiline for more than 24 weeks was not associated with a high level of adverse reactions. It was found that the use of cycloserine/terizidone made a significant contribution to the favorable outcome of chemotherapy. The factors associated with the most unfavorable treatment outcomes were the following: age above 60 years, concurrent chronic obstructive pulmonary disease, alcohol and/or drug addiction, and smoking. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 2075-1230 2542-1506 |
| Relation: | https://www.tibl-journal.com/jour/article/view/1445; https://doaj.org/toc/2075-1230; https://doaj.org/toc/2542-1506 |
| DOI: | 10.21292/2075-1230-2020-98-7-56-62 |
| URL الوصول: | https://doaj.org/article/6f4bc3f16a9141cd816698f93e3d9245 |
| رقم الأكسشن: | edsdoj.6f4bc3f16a9141cd816698f93e3d9245 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20751230 25421506 |
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| DOI: | 10.21292/2075-1230-2020-98-7-56-62 |