دورية أكاديمية
Low in vitro activity of sertaconazole against clinical isolates of dermatophyte
| العنوان: | Low in vitro activity of sertaconazole against clinical isolates of dermatophyte |
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| المؤلفون: | Mahsa Behnam, Hossein Zarrinfar, Mohammad Javad Najafzadeh, Ali Naseri, Lida Jarahi, Monika Novak Babič |
| المصدر: | Current Medical Mycology, Vol 6, Iss 1, Pp 36-41 (2020) |
| بيانات النشر: | Mazandaran University of Medical Sciences, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Internal medicine LCC:Biology (General) |
| مصطلحات موضوعية: | antifungal drugs, dermatophytes, mashhad, microdilution, sertaconazole, Internal medicine, RC31-1245, Biology (General), QH301-705.5 |
| الوصف: | Background and Purpose: Dermatophytes are a group of fungi specialized in invading humans and other vertebrate keratinized tissues. These fungi cause a variety of skin, nail, and hair disorders, called dermatophytosis (tinea). In some cases, drug resistance to antifungals necessitates special treatment. Among the antifungal agents, sertaconazole (i.e., a third-generation imidazole) has a broad-spectrum against dermatophyte species. Regarding this, the present study was conducted to investigate the antifungal susceptibility of dermatophytes obtained from patients with dermatophytosis in Mashhad located in northeastern Iran. Materials and Methods: A total of 75 clinical dermatophyte isolates, including Trichophyton mentagrophytes (n=21), T. interdigitale (n=18), T. tonsurans (n=16), Epidermophyton floccosum (n=11), Microsporum canis (n=5), Nannizzia fulvum (n=2), T. benhamiae (n=1), and T. verrucosum (n=1), were evaluated against five antifungal agents of sertaconazole, itraconazole, clotrimazole, terbinafine, and griseofulvin based on the CLSI M38-A2 guideline. Results: According to the results, the minimum inhibitory concentration (MIC) ranges of sertaconazole, terbinafine, griseofulvin, itraconazole, and clotrimazole were estimated at 0.125-16, 0.002-1, 0.5-4, 0.031-4, and 0.016-4 μg/ml, respectively, for dermatophyte species. In addition, the geometric mean (GM) values of the MIC of sertaconazole, terbinafine, griseofulvin, itraconazole, and clotrimazole were obtained as 3.39, 1, 1.44, 1.52, and 1.93, respectively. Conclusion: Among the tested antifungals, terbinafine and griseofulvin were the most effective agents against dermatophyte isolates. However, sertaconazole, a third-generation imidazole, did not show any significant effect. Furthermore, M. canis and E. floccosum showed the best response to the antifungal agents. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2423-3439 2423-3420 |
| Relation: | http://cmm.mazums.ac.ir/article_101510_88ac1149fb06db783b35de3aed29f846.pdf; https://doaj.org/toc/2423-3439; https://doaj.org/toc/2423-3420 |
| DOI: | 10.18502/cmm.6.1.2507 |
| URL الوصول: | https://doaj.org/article/6f5719980213442dad097ba487948cfd |
| رقم الأكسشن: | edsdoj.6f5719980213442dad097ba487948cfd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24233439 24233420 |
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| DOI: | 10.18502/cmm.6.1.2507 |