دورية أكاديمية
happi: a hierarchical approach to pangenomics inference
| العنوان: | happi: a hierarchical approach to pangenomics inference |
|---|---|
| المؤلفون: | Pauline Trinh, David S. Clausen, Amy D. Willis |
| المصدر: | Genome Biology, Vol 24, Iss 1, Pp 1-15 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biology (General) LCC:Genetics |
| مصطلحات موضوعية: | Shotgun metagenomics, Metagenome-assembled genomes, Microbiome, Statistical models, Hypothesis testing, Biology (General), QH301-705.5, Genetics, QH426-470 |
| الوصف: | Abstract Recovering metagenome-assembled genomes (MAGs) from shotgun sequencing data is an increasingly common task in microbiome studies, as MAGs provide deeper insight into the functional potential of both culturable and non-culturable microorganisms. However, metagenome-assembled genomes vary in quality and may contain omissions and contamination. These errors present challenges for detecting genes and comparing gene enrichment across sample types. To address this, we propose happi, an approach to testing hypotheses about gene enrichment that accounts for genome quality. We illustrate the advantages of happi over existing approaches using published Saccharibacteria MAGs, Streptococcus thermophilus MAGs, and via simulation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1474-760X |
| Relation: | https://doaj.org/toc/1474-760X |
| DOI: | 10.1186/s13059-023-03040-6 |
| URL الوصول: | https://doaj.org/article/6f73b8bc342d44ea829ff6fba2400e07 |
| رقم الأكسشن: | edsdoj.6f73b8bc342d44ea829ff6fba2400e07 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1474760X |
|---|---|
| DOI: | 10.1186/s13059-023-03040-6 |