دورية أكاديمية
Molecular Mechanisms of Fetal Tendon Regeneration Versus Adult Fibrous Repair
| العنوان: | Molecular Mechanisms of Fetal Tendon Regeneration Versus Adult Fibrous Repair |
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| المؤلفون: | Iris Ribitsch, Andrea Bileck, Alexander D. Aldoshin, Maciej M. Kańduła, Rupert L. Mayer, Monika Egerbacher, Simone Gabner, Ulrike Auer, Sinan Gültekin, Johann Huber, David P. Kreil, Christopher Gerner, Florien Jenner |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 11, p 5619 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | tendon healing, regeneration, inflammation, tendinopathy, proteomics, animal model, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Tendinopathies are painful, disabling conditions that afflict 25% of the adult human population. Filling an unmet need for realistic large-animal models, we here present an ovine model of tendon injury for the comparative study of adult scarring repair and fetal regeneration. Complete regeneration of the fetal tendon within 28 days is demonstrated, while adult tendon defects remained macroscopically and histologically evident five months post-injury. In addition to a comprehensive histological assessment, proteome analyses of secretomes were performed. Confirming histological data, a specific and pronounced inflammation accompanied by activation of neutrophils in adult tendon defects was observed, corroborated by the significant up-regulation of pro-inflammatory factors, neutrophil attracting chemokines, the release of potentially tissue-damaging antimicrobial and extracellular matrix-degrading enzymes, and a response to oxidative stress. In contrast, secreted proteins of injured fetal tendons included proteins initiating the resolution of inflammation or promoting functional extracellular matrix production. These results demonstrate the power and relevance of our novel ovine fetal tendon regeneration model, which thus promises to accelerate research in the field. First insights from the model already support our molecular understanding of successful fetal tendon healing processes and may guide improved therapeutic strategies. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/22/11/5619; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms22115619 |
| URL الوصول: | https://doaj.org/article/6f816c73e95b47f19f90ea691173ccb5 |
| رقم الأكسشن: | edsdoj.6f816c73e95b47f19f90ea691173ccb5 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms22115619 |