دورية أكاديمية
Biological Activity and Thrombogenic Properties of Oxide Nanotubes on the Ti-13Nb-13Zr Biomedical Alloy
| العنوان: | Biological Activity and Thrombogenic Properties of Oxide Nanotubes on the Ti-13Nb-13Zr Biomedical Alloy |
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| المؤلفون: | Agnieszka Stróż, Maciej Gawlikowski, Katarzyna Balin, Patrycja Osak, Julian Kubisztal, Maciej Zubko, Joanna Maszybrocka, Karolina Dudek, Bożena Łosiewicz |
| المصدر: | Journal of Functional Biomaterials, Vol 14, Iss 7, p 375 (2023) |
| بيانات النشر: | MDPI AG, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Biotechnology LCC:Medicine (General) |
| مصطلحات موضوعية: | anodization, biological activity, biomaterials, drug delivery system, oxide nanotubes, Ti-13Nb-13Zr alloy, Biotechnology, TP248.13-248.65, Medicine (General), R5-920 |
| الوصف: | The success of implant treatment is dependent on the osseointegration of the implant. The main goal of this work was to improve the biofunctionality of the Ti-13Nb-13Zr implant alloy by the production of oxide nanotubes (ONTs) layers for better anchoring in the bone and use as an intelligent carrier in drug delivery systems. Anodization of the Ti-13Nb-13Zr alloy was carried out in 0.5% HF, 1 M (NH4)2SO4 + 2% NH4F, and 1 M ethylene glycol + 4 wt.% NH4F electrolytes. Physicochemical characteristics of ONTs were performed by high-resolution electron microscopy (HREM), X-ray photoelectron spectroscopy (XPS), and scanning Kelvin probe (SKP). Water contact angle studies were conducted using the sitting airdrop method. In vitro biological properties and release kinetics of ibuprofen were investigated. The results of TEM and XPS studies confirmed the formation of the single-walled ONTs of three generations on the bi-phase (α + β) Ti-13Nb-13Zr alloy. The ONTs were composed of oxides of the alloying elements. The proposed surface modification method ensured good hemolytic properties, no cytotoxity for L-929 mouse cells, good adhesion, increased surface wettability, and improved athrombogenic properties of the Ti-13Nb-13Zr alloy. Nanotubular surfaces allowed ibuprofen to be released from the polymer matrix according to the Gallagher–Corrigan model. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 14070375 2079-4983 |
| Relation: | https://www.mdpi.com/2079-4983/14/7/375; https://doaj.org/toc/2079-4983 |
| DOI: | 10.3390/jfb14070375 |
| URL الوصول: | https://doaj.org/article/6fa0a10c7a964894b8a88ecb510129b3 |
| رقم الأكسشن: | edsdoj.6fa0a10c7a964894b8a88ecb510129b3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14070375 20794983 |
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| DOI: | 10.3390/jfb14070375 |