دورية أكاديمية
Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages
| العنوان: | Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages |
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| المؤلفون: | Andrea Santeford, Aaron Y Lee, Abdoulaye Sene, Lynn M Hassman, Alexey A Sergushichev, Ekaterina Loginicheva, Maxim N Artyomov, Philip A Ruzycki, Rajendra S Apte |
| المصدر: | eLife, Vol 10 (2021) |
| بيانات النشر: | eLife Sciences Publications Ltd, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Science LCC:Biology (General) |
| مصطلحات موضوعية: | macrophage, aging, mitochondrial metabolism, Medicine, Science, Biology (General), QH301-705.5 |
| الوصف: | Macrophages undergo programmatic changes with age, leading to altered cytokine polarization and immune dysfunction, shifting these critical immune cells from protective sentinels to disease promoters. The molecular mechanisms underlying macrophage inflammaging are poorly understood. Using an unbiased RNA sequencing (RNA-seq) approach, we identified Mir146b as a microRNA whose expression progressively and unidirectionally declined with age in thioglycollate-elicited murine macrophages. Mir146b deficiency led to altered macrophage cytokine expression and reduced mitochondrial metabolic activity, two hallmarks of cellular aging. Single-cell RNA-seq identified patterns of altered inflammation and interferon gamma signaling in Mir146b-deficient macrophages. Identification of Mir146b as a potential regulator of macrophage aging provides novel insights into immune dysfunction associated with aging. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2050-084X |
| Relation: | https://elifesciences.org/articles/66703; https://doaj.org/toc/2050-084X |
| DOI: | 10.7554/eLife.66703 |
| URL الوصول: | https://doaj.org/article/6fb8d853a91b4d1da48547761a3b3cc2 |
| رقم الأكسشن: | edsdoj.6fb8d853a91b4d1da48547761a3b3cc2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2050084X |
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| DOI: | 10.7554/eLife.66703 |