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Aspidosperma pyrifolium Has Anti-Inflammatory Properties: An Experimental Study in Mice with Peritonitis Induced by Tityus serrulatus Venom or Carrageenan

التفاصيل البيبلوغرافية
العنوان: Aspidosperma pyrifolium Has Anti-Inflammatory Properties: An Experimental Study in Mice with Peritonitis Induced by Tityus serrulatus Venom or Carrageenan
المؤلفون: Maíra Conceição Jerônimo de Souza Lima, Mariana Angélica Oliveira Bitencourt, Allanny Alves Furtado, Manoela Torres-Rêgo, Emerson Michell da Silva Siqueira, Ruth Medeiros Oliveira, Hugo Alexandre Oliveira Rocha, Keyla Borges Ferreira Rocha, Arnóbio Antônio da Silva-Júnior, Silvana Maria Zucolotto, Matheus de Freitas Fernandes-Pedrosa
المصدر: International Journal of Molecular Sciences, Vol 18, Iss 11, p 2248 (2017)
بيانات النشر: MDPI AG, 2017.
سنة النشر: 2017
المجموعة: LCC:Biology (General)
LCC:Chemistry
مصطلحات موضوعية: anti-inflammatory activity, Aspidosperma pyrifolium, carrageenan, rutin, scorpion venom, Tityus serrulatus, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Scorpions of the genus Tityus are responsible for the majority of envenomation in Brazil, the Tityus serrulatus species being the most common and dangerous in South America. In this approach, we have investigated the ability of the aqueous extract from the leaves of Aspidosperma pyrifolium in reducing carrageenan-induced inflammation and the inflammation induced by T. serrulatus envenomation in mice. We also evaluated the cytotoxic effects of this extract, using the 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl-2H-tetrazolium (MTT) assay and the results revealed that the extract is safe. Analysis by High Performance Liquid Chromatography coupled with Diode Array Detector (HPLC-DAD) and Liquid Chromatography Coupled with Mass Spectrometry with Diode Array Detection (LC-DAD-MS) showed one major chemical component, the flavonoid rutin and phenolics compounds. For in vivo studies in carrageenan-induced peritonitis model, mice received extracts, dexamethasone, rutin or saline, before administration of carrageenan. For venom-induced inflammation model, animals received T. serrulatus venom and were, simultaneously, treated with extracts, antivenom, rutin or saline. The extract and rutin showed a reduction in the cell migration into the peritoneal cavity, and in the same way the envenomated animals also showed reduction of edema, inflammatory cell infiltration and vasodilation in lungs. This is an original study revealing the potential action of A. pyrifolium against inflammation caused by Tityus serrulatus venom and carrageenan, revealing that this extract and its bioactive molecules, specifically rutin, may present potential anti-inflammatory application.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1422-0067
Relation: https://www.mdpi.com/1422-0067/18/11/2248; https://doaj.org/toc/1422-0067
DOI: 10.3390/ijms18112248
URL الوصول: https://doaj.org/article/a6fd70d1c5914b5b86679540ca09085a
رقم الأكسشن: edsdoj.6fd70d1c5914b5b86679540ca09085a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:14220067
DOI:10.3390/ijms18112248