دورية أكاديمية
Mendelian randomization evidence based on European ancestry for the causal effects of leukocyte telomere length on prostate cancer
| العنوان: | Mendelian randomization evidence based on European ancestry for the causal effects of leukocyte telomere length on prostate cancer |
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| المؤلفون: | Xinrui Wu, Cong Hu, Tianyang Wu, Xinxing Du, Zehong Peng, Wei Xue, Yonghui Chen, Liang Dong |
| المصدر: | Human Genomics, Vol 18, Iss 1, Pp 1-12 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine LCC:Genetics |
| مصطلحات موضوعية: | Medicine, Genetics, QH426-470 |
| الوصف: | Abstract Background Several lines of evidence suggest that leukocyte telomere length (LTL) can affect the development of prostate cancer (PC). Methods Here, we employed single nucleoside polymorphisms (SNPs) as instrumental variables (IVs) for LTL (n = 472,174) and conducted Mendelian randomization analysis to estimate their causal impact on PCs (79,148 patients/61,106 controls and 6311 patients/88,902 controls). Results Every 1-s.d extension of LTL increased the risk of PCs by 34%. Additionally, the analysis of candidate mediators between LTL and PCs via two-step Mendelian randomization revealed that among the 23 candidates, Alzheimer’s disease, liver iron content, sex hormone binding global levels, naive CD4–CD8-T cell% T cell, and circulating leptin levels played substantial mediating roles. There is no robust evidence to support the reverse causal relationship between LTL and the selected mediators of PCs. Adjusting for the former four mediators, rather than adjusting for circulating leptin levels, decreased the impact of LTL on PCs. Conclusion This study provides potential intervention measures for preventing LTL-induced PCs. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1479-7364 |
| Relation: | https://doaj.org/toc/1479-7364 |
| DOI: | 10.1186/s40246-024-00622-8 |
| URL الوصول: | https://doaj.org/article/d6feb642cf5f46bc8bb85e28d9484544 |
| رقم الأكسشن: | edsdoj.6feb642cf5f46bc8bb85e28d9484544 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14797364 |
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| DOI: | 10.1186/s40246-024-00622-8 |