دورية أكاديمية
Platelet Activating Factor Synthesis and Metabolism in Intestinal Ischaemia-Reperfusion Injury
| العنوان: | Platelet Activating Factor Synthesis and Metabolism in Intestinal Ischaemia-Reperfusion Injury |
|---|---|
| المؤلفون: | M. J. Mangino, M. Murphy, A. Bohrer, J. Turk |
| المصدر: | Mediators of Inflammation, Vol 3, Iss 5, Pp 393-395 (1994) |
| بيانات النشر: | Hindawi Limited, 1994. |
| سنة النشر: | 1994 |
| المجموعة: | LCC:Pathology |
| مصطلحات موضوعية: | Pathology, RB1-214 |
| الوصف: | The object of this study was to characterize the synthesis and metabolism of platelet activating factor (PAF) by intestinal mucosa subjected to ischaemia–reperfusion injury. Canine intestinal mucosa produced 16:0-PAF, 18:0-PAF, and high levels of the corresponding lyso- PAF metabolites. Three h of intestinal ischaemia and ischaemia followed by 1 h of reperfusion did not affect the synthesis or metabolism of PAF by intestinal mucosa. Intestinal mucosa elaborated a factor that rapidly hydrolyzes PAF to lyso-PAF. The observed hydrolysis rate was not altered by ischaemia or ischaemia and reperfusion. In conclusion, this study suggests that intestinal mucosa produces PAF and rapidly hydrolyzes PAF. The PAF synthesis and metabolism rates of intestinal mucosa is not altered by ischaemia reperfusion in this model under the imposed conditions. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0962-9351 1466-1861 09629351 |
| Relation: | https://doaj.org/toc/0962-9351; https://doaj.org/toc/1466-1861 |
| DOI: | 10.1155/S0962935194000554 |
| URL الوصول: | https://doaj.org/article/704a9cf7c7cb40dbabe1529f7a36cff1 |
| رقم الأكسشن: | edsdoj.704a9cf7c7cb40dbabe1529f7a36cff1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09629351 14661861 |
|---|---|
| DOI: | 10.1155/S0962935194000554 |