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Quality Control of Motor Unit Number Index (MUNIX) Measurements in 6 Muscles in a Single-Subject 'Round-Robin' Setup.

التفاصيل البيبلوغرافية
العنوان: Quality Control of Motor Unit Number Index (MUNIX) Measurements in 6 Muscles in a Single-Subject 'Round-Robin' Setup.
المؤلفون: Christoph Neuwirth, Christian Burkhardt, James Alix, José Castro, Mamede de Carvalho, Malgorzata Gawel, Stephan Goedee, Julian Grosskreutz, Timothée Lenglet, Cristina Moglia, Taha Omer, Maarten Schrooten, Markus Weber
المصدر: PLoS ONE, Vol 11, Iss 5, p e0153948 (2016)
بيانات النشر: Public Library of Science (PLoS), 2016.
سنة النشر: 2016
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND:Motor Unit Number Index (MUNIX) is a neurophysiological measure that provides an index of the number of lower motor neurons in a muscle. Its performance across centres in healthy subjects and patients with Amyotrophic Lateral Sclerosis (ALS) has been established, but inter-rater variability between multiple raters in one single subject has not been investigated. OBJECTIVE:To assess reliability in a set of 6 muscles in a single subject among 12 examiners (6 experienced with MUNIX, 6 less experienced) and to determine variables associated with variability of measurements. METHODS:Twelve raters applied MUNIX in six different muscles (abductor pollicis brevis (APB), abductor digiti minimi (ADM), biceps brachii (BB), tibialis anterior (TA), extensor dig. brevis (EDB), abductor hallucis (AH)) twice in one single volunteer on consecutive days. All raters visited at least one training course prior to measurements. Intra- and inter-rater variability as determined by the coefficient of variation (COV) between different raters and their levels of experience with MUNIX were compared. RESULTS:Mean intra-rater COV of MUNIX was 14.0% (±6.4) ranging from 5.8 (APB) to 30.3% (EDB). Mean inter-rater COV was 18.1 (±5.4) ranging from 8.0 (BB) to 31.7 (AH). No significant differences of variability between experienced and less experienced raters were detected. CONCLUSION:We provide evidence that quality control for neurophysiological methods can be performed with similar standards as in laboratory medicine. Intra- and inter-rater variability of MUNIX is muscle-dependent and mainly below 20%. Experienced neurophysiologists can easily adopt MUNIX and adequate teaching ensures reliable utilization of this method.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC4852906?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0153948
URL الوصول: https://doaj.org/article/70580f75862c402eb370b4b7a7d4a6af
رقم الأكسشن: edsdoj.70580f75862c402eb370b4b7a7d4a6af
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0153948