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Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB.

التفاصيل البيبلوغرافية
العنوان: Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB.
المؤلفون: Giuseppe Fiume, Annalisa Rossi, Annamaria de Laurentiis, Cristina Falcone, Antonio Pisano, Eleonora Vecchio, Marilena Pontoriero, Iris Scala, Annarita Scialdone, Francesca Fasanella Masci, Selena Mimmi, Camillo Palmieri, Giuseppe Scala, Ileana Quinto
المصدر: PLoS ONE, Vol 8, Iss 6, p e66087 (2013)
بيانات النشر: Public Library of Science (PLoS), 2013.
سنة النشر: 2013
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Protein synthesis is mainly regulated at the initiation step, allowing the fast, reversible and spatial control of gene expression. Initiation of protein synthesis requires at least 13 translation initiation factors to assemble the 80S ribosomal initiation complex. Loss of translation control may result in cell malignant transformation. Here, we asked whether translational initiation factors could be regulated by NF-κB transcription factor, a major regulator of genes involved in cell proliferation, survival, and inflammatory response. We show that the p65 subunit of NF-κB activates the transcription of eIF4H gene, which is the regulatory subunit of eIF4A, the most relevant RNA helicase in translation initiation. The p65-dependent transcriptional activation of eIF4H increased the eIF4H protein content augmenting the rate of global protein synthesis. In this context, our results provide novel insights into protein synthesis regulation in response to NF-κB activation signalling, suggesting a transcription-translation coupled mechanism of control.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23776612/?tool=EBI; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0066087
URL الوصول: https://doaj.org/article/70804be5609d42638ceaeb65619a3747
رقم الأكسشن: edsdoj.70804be5609d42638ceaeb65619a3747
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0066087