دورية أكاديمية
Effect of antagonist start day on cycle outcomes in poor responders
| العنوان: | Effect of antagonist start day on cycle outcomes in poor responders |
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| المؤلفون: | Inci Kahyaoglu, Hatice Y Dogru, Iskender Kaplanoglu, Ayse Seval Ozgu-Erdinc, Serdar Dilbaz, Leyla Mollamahmutoglu |
| المصدر: | Journal of Human Reproductive Sciences, Vol 14, Iss 4, Pp 400-405 (2021) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Gynecology and obstetrics |
| مصطلحات موضوعية: | bologna criteria, controlled ovarian stimulation, decreased ovarian reserve, gonadotropin releasing hormone-antagonist, Gynecology and obstetrics, RG1-991 |
| الوصف: | Background: Despite the great advances in Assisted Reproductive Technologies (ART), management of poor responders has remained a great challenge. Gonadotropin releasing hormone antagonist (GnRH-ant) has been offered as a patient friendly protocol. In the literature, conflicting data exists about the effect of the GnRH-ant starting day on cycle outcomes. Aim: The aim of this study is to evaluate the effect of GnRH-ant starting day on cycle outcomes of patients with poor ovarian response defined by Bologna criteria. Setting and Design: This retrospective cohort study was conducted at an ART clinic of a tertiary hospital. Materials and Methods: A total of 361 cycles using flexible GnRH-ant, 195 in Group A (GnRH-ant administered before day 6 of stimulation) and 166 cycles in Group B (GnRH-ant started on or after day 6), were selected retrospectively for the study. Statistical analysis: Statistical analysis of data was carried out using using IBM SPSS Statistics Software (20.0, SPSS Inc., Chicago, IL, USA). Independent samples t-test and Mann–Whitney U test were used to analyze the variables. Results: Total antral follicle count was significantly higher in Group A compared to Group B (P = 0.009). Duration of stimulation was significantly shorter (P < 0.01) and total dose of gonadotropin used was lower in Group A when compared to Group B (P < 0.01). While higher number of oocytes was retrieved from Group A (P = 0.037), no between-group differences were observed in number of mature oocytes, fertilized oocytes, clinical pregnancy rate or ongoing pregnancy rate (OPR) per embryo transfer (P > 0.05). Conclusion: Early GnRH-ant start may point out a favourable response to ovarian stimulation in poor responders. However, clinical or OPRs were not different from the late GnRH-ant start group. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0974-1208 1998-4766 |
| Relation: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=4;spage=400;epage=405;aulast=Kahyaoglu; https://doaj.org/toc/0974-1208; https://doaj.org/toc/1998-4766 |
| DOI: | 10.4103/jhrs.jhrs_75_21 |
| URL الوصول: | https://doaj.org/article/70876a6d968740998fbfeca7b940a65d |
| رقم الأكسشن: | edsdoj.70876a6d968740998fbfeca7b940a65d |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 09741208 19984766 |
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| DOI: | 10.4103/jhrs.jhrs_75_21 |