دورية أكاديمية
Anti-Aging Effect of Dietary Fiber Compound Mediated by Guangxi Longevity Dietary Pattern on Natural Aging Mice
| العنوان: | Anti-Aging Effect of Dietary Fiber Compound Mediated by Guangxi Longevity Dietary Pattern on Natural Aging Mice |
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| المؤلفون: | Xiaohan Yu, Xiaolin Liang, Kunchen Han, Fengcui Shi, Ning Meng, Quanyang Li |
| المصدر: | Nutrients, Vol 14, Iss 15, p 3181 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Nutrition. Foods and food supply |
| مصطلحات موضوعية: | characteristic dietary fiber compound, natural aging mice, bidirectional adjustment, antioxidant, gut microbes, optimal intake parameters, Nutrition. Foods and food supply, TX341-641 |
| الوصف: | A series of previous studies by our team has shown that the Guangxi longevity dietary pattern contributes to the improvement of human health, but the role of dietary fiber compounds (DFC) in the anti-aging of this dietary pattern has not been studied in depth. Thus, mice were fed with 5%, 15%, and 30% of the characteristic dietary fiber compound (CDFC) (compounded according to the longevity dietary pattern) for 8 weeks, and their learning memory capacity, antioxidant capacity, and inflammatory markers, as well as typical microorganisms in the intestinal tract were analyzed to investigate the anti-aging effects of the CDFC under the Guangxi longevity dietary pattern on naturally aging mice. The results showed that CDFC had a bidirectional effect on body weight regulation; increased brain, spleen, and cardiac indices, of which the medium dose was the best. Meanwhile, CDFC also had a maintenance and improvement effect on learning and memory ability in aging mice, as well as improved antioxidant capacity and reduced inflammation level. The neuronal cell necrosis in the hippocampus of mice was effectively alleviated. The expression of Escherichia coli and Bacteroides was significantly reduced, and the expression of Bifidobacterium and Lactobacillus increased. In addition, the optimal amount of CDFC added from the level of experimental animals was in a certain interval above and below 15%. The combined results indicated that CDFC mediated by the Guangxi longevity dietary pattern had significant anti-aging effects, thus theoretically proving that dietary fiber compound contributes to human longevity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 14153181 2072-6643 |
| Relation: | https://www.mdpi.com/2072-6643/14/15/3181; https://doaj.org/toc/2072-6643 |
| DOI: | 10.3390/nu14153181 |
| URL الوصول: | https://doaj.org/article/70985d0d43ef4462925cf11f2d7d765f |
| رقم الأكسشن: | edsdoj.70985d0d43ef4462925cf11f2d7d765f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14153181 20726643 |
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| DOI: | 10.3390/nu14153181 |