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أعرض في EDS

Frequency distribution of IL-17A G197A (rs2275913) and IL-17F A7488G (rs763780) polymorphisms among healthy Sudanese population

التفاصيل البيبلوغرافية
العنوان: Frequency distribution of IL-17A G197A (rs2275913) and IL-17F A7488G (rs763780) polymorphisms among healthy Sudanese population
المؤلفون: Nouh S. Mohamed, Emmanuel E. Siddig, Abdallah E. Ahmed, Musab M. A. Albsheer, Hanadi Abdelbagi, Eman T. Ali, Anadel A. Alsubki, Sabah A. Abdalaziz, Madinna Mustafa, Mohamed S. Muneer, Hussam A. Osman, Maha M. Osman, Mohamed S. Ali, Ali M. M. Edris, Ayman Ahmed, Rihab A. Omer
المصدر: BMC Research Notes, Vol 13, Iss 1, Pp 1-7 (2020)
بيانات النشر: BMC, 2020.
سنة النشر: 2020
المجموعة: LCC:Medicine
LCC:Biology (General)
LCC:Science (General)
مصطلحات موضوعية: Interleukin 17A, Interleukin 17F, Polymorphism, Healthy population, Sudan, Medicine, Biology (General), QH301-705.5, Science (General), Q1-390
الوصف: Abstract Objectives IL-17A G197A and IL-17F A7488G polymorphisms has been identified to be associated with the susceptibility to many diseases. This study aimed to investigate the frequency distribution of IL-17A G197A and IL-17F A7488G polymorphisms among healthy Sudanese population. A descriptive cross-sectional hospital-based molecular study conducted in different sites throughout Sudan. Two ml blood samples were collected from 717 healthy participants. Demographic data and the medical history of the participants were collected. Results Of the 717 participants, 355 (49.5%) were males and 362 (50.5%) were females, their mean age was 30.2 ± 17.2 and 32.2 ± 16.5, respectively. For IL-17A, the most frequent genotype detected among males and females was IL-17A heterozygote allele (AG); 215 (60.6%) and 194 (53.6%), respectively. Whereas, for IL-17F, the most frequent allele among males and females was the homozygote allele (AA); 298 (83.9%) for males and 322 (89.0%) for females. HWE for genotype distributions of IL-17A was showing statistical insignificance for IL-17A among males and females, P value 0.614. While HWE for IL-17F reached the equilibrium level, P value 0.048. The most frequent age group was those aged between 21 to 40 years; 281 (39.2%). Arab constituted the major ethnicity of the study participants; 418 (58.3%), P value 0.034.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1756-0500
Relation: http://link.springer.com/article/10.1186/s13104-020-05165-4; https://doaj.org/toc/1756-0500
DOI: 10.1186/s13104-020-05165-4
URL الوصول: https://doaj.org/article/d709a38d46864a3cb32ea624ffc46b74
رقم الأكسشن: edsdoj.709a38d46864a3cb32ea624ffc46b74
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:17560500
DOI:10.1186/s13104-020-05165-4