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Is there an association between type 1 diabetes in children and gallbladder stones formation?

التفاصيل البيبلوغرافية
العنوان: Is there an association between type 1 diabetes in children and gallbladder stones formation?
المؤلفون: Abdulrahman A Al-Hussaini, Ahmed S Alenizi, Musa D AlZahrani, Nimer M Sulaiman, Mannan Khan
المصدر: The Saudi Journal of Gastroenterology, Vol 19, Iss 2, Pp 86-88 (2013)
بيانات النشر: Wolters Kluwer Medknow Publications, 2013.
سنة النشر: 2013
المجموعة: LCC:Diseases of the digestive system. Gastroenterology
مصطلحات موضوعية: Child, gall stones, Saudi Arabia, type 1 diabetes, ultrasound, Diseases of the digestive system. Gastroenterology, RC799-869
الوصف: Background and Aims: A number of studies in adults have evaluated the prevalence of gallstones in the diabetic population and showed a significant association with type 1 diabetes (T1D) and type 2 diabetes. The pediatric literature is limited to a single small case series. We conducted a cross-sectional study to evaluate for the presence of association between T1D in children and gallstones formation. Patients and Methods: Children diagnosed with T1D in a diabetic clinic have been examined for existence of gall bladder stone formation from November 2008 through November 2009. All have been subjected to the following: History, physical examination, blood tests (liver function tests, lipid profile, glycosylated hemoglobin [HbA1C]), and an ultrasound (US) of the gall bladder. Results: One hundred and five children with T1D have been enrolled consecutively over a 1-year period: age ranged between 8 months and 15.5 years, 62 patients were females. The mean age at diagnosis was 6.3 ± 2.9 years (range 0.85-11 years), mean duration of T1D was 2.2 ± 2.1 years (range 0.2-8 years), mean body mass index was 16.5 ± 3.4, mean HbA1c was 10.7 ± 2.4%, and 61.3% of patients had a HbA1c level >10%. The mean serum cholesterol was 4.16 ± 0.75 mmol/L (normal 3.65-5.15 mmol/L) and mean serum triglyceride 1.02 ± 1.3 mmol/L (normal 0-1.7 mmol/L). Two patients had hyperlipidemia. US of the gallbladder did not show any case of gallstones or sludge formation. Conclusion: Data from our study do not show any association between T1D in children and gallstones formation, with diabetes duration of less than 8 years. The relatively short duration of diabetes and possibility that our study was underpowered might have been reasons for the absence of any association.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1319-3767
1998-4049
Relation: http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2013;volume=19;issue=2;spage=86;epage=88;aulast=Al-Hussaini; https://doaj.org/toc/1319-3767; https://doaj.org/toc/1998-4049
DOI: 10.4103/1319-3767.108482
URL الوصول: https://doaj.org/article/70a05a9621894af19ca16b5097e8cc9e
رقم الأكسشن: edsdoj.70a05a9621894af19ca16b5097e8cc9e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:13193767
19984049
DOI:10.4103/1319-3767.108482