دورية أكاديمية
Up-Regulation of Intrarenal Renin-Agiotensin System Contributes to Renal Damage in High-Salt Induced Hypertension Rats
| العنوان: | Up-Regulation of Intrarenal Renin-Agiotensin System Contributes to Renal Damage in High-Salt Induced Hypertension Rats |
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| المؤلفون: | Haiyan Wu, Yaoxian Liang, Yimu Zheng, Qiong Bai, Zheng Zhuang, Lata A, Danxia Zheng, Yue Wang |
| المصدر: | Kidney & Blood Pressure Research, Vol 39, Iss 6, Pp 526-535 (2014) |
| بيانات النشر: | Karger Publishers, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Dermatology LCC:Diseases of the circulatory (Cardiovascular) system LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | Hypertension, Intrarenal RAS, Angiotensinogen, Angiotensin II, High-salt diet, Dermatology, RL1-803, Diseases of the circulatory (Cardiovascular) system, RC666-701, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Background/Aims: To investigate the change of intrarenal renin-agiotensin system (RAS) and its role in high-salt induced hypertension. Methods: Wistar rats were divided into normal-salt (NS), high-salt diet (HS) and high-salt diet with Losartan group (HS+L), for 6 weeks. Systolic blood pressure (SBP) was monitored. Blood and urine samples were collected every 2 weeks. Angiotensinogen (AGT) was measured by ELISA. AGT mRNA and protein were measured by real-time PCR and immunohistochemistry. Renin activity and angiotensin II (Ang II) were measured by radioimmunoassay. Results: HS versus NS group, SBP increased from 2nd week (Pth week (PP>0.05), renal cortex renin, AGT, and Ang II increased significantly in HS (PP>0.05) but abolished the increase of proteinuria (PPPP P Conclusion: Inappropriate response of the renal RAS to a high salt diet may contribute to hypertension and renal damage, and urinary AGT could reflect intrarenal RAS activity. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1420-4096 1423-0143 00036846 |
| Relation: | http://www.karger.com/Article/FullText/368463; https://doaj.org/toc/1420-4096; https://doaj.org/toc/1423-0143 |
| DOI: | 10.1159/000368463 |
| URL الوصول: | https://doaj.org/article/70bff8b7f9cd4139b75cee740199db20 |
| رقم الأكسشن: | edsdoj.70bff8b7f9cd4139b75cee740199db20 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 14204096 14230143 00036846 |
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| DOI: | 10.1159/000368463 |