دورية أكاديمية
Clinical aspects of sclerodermatous type graft-versus-host disease after allogeneic hematopoietic cell transplantation
| العنوان: | Clinical aspects of sclerodermatous type graft-versus-host disease after allogeneic hematopoietic cell transplantation |
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| المؤلفون: | Hatice Şanlı, Bengü Nisa Akay, Ender Soydan, Pelin Koçyiğit, Mutlu Arat, Osman İlhan |
| المصدر: | Turkish Journal of Hematology, Vol 27, Iss 02, Pp 91-98 (2010) |
| بيانات النشر: | Galenos Publishing House, 2010. |
| سنة النشر: | 2010 |
| المجموعة: | LCC:Diseases of the blood and blood-forming organs |
| مصطلحات موضوعية: | Allogeneic hematopoietic stem cell transplantation, sclerodermatous graft-versus-host disease, Diseases of the blood and blood-forming organs, RC633-647.5 |
| الوصف: | Objective: We aimed to evaluate the clinical features of sclerodermatous chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (AHSCT).Materials and Methods: We retrospectively analyzed 423 patients who underwent AHSCT. We assessed age, sex, pre-transplant diagnosis, conditioning regimen, GVHD prophylaxis, and occurrence of acute GVHD (aGVHD), chronic lichenoid and chronic systemic GVHD, and clinical properties of sclerodermatous GVHD. Results: Sclerotic skin lesions developed in 22 patients after a mean of 752±647 days (median 480). aGVHD appeared in 17 patients, with hepatic involvement in 2, gastrointestinal tract involvement in 2 and skin involvement in 13 of these patients. Extensive chronic GVHD (liver, pulmonary, skin and oral mucosa) developed in 12 patients. Sclerosis was generalized in 19 patients (86.4%) and localized in 3 patients (13.6%). Leopard skin eruption appeared in 8 (36.4%) of the 19 patients with generalized sclerodermatous changes. In most cases, sclerotic lesions appeared on the trunk, and distal parts of the extremities were spared. Eight patients (36.4%) progressed from lichenoid to sclerodermatous lesions, 2 (9.1%) with lichenoid and sclerodermatous phases together and 12 (55.5%) with de novo sclerodermatous lesions. Five patients died because of late transplant-related complications. Conclusion: Sclerodermatous GVHD has a late onset and may be quite disabling. Unlike scleroderma, acral involvement is seen rarely. Although most lesions do not disappear in the course of the disease, most patients have a good prognosis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1300-7777 1308-5263 |
| Relation: | http://www.journalagent.com/z4/download_fulltext.asp?pdir=tjh&plng=eng&un=TJH-25238; https://doaj.org/toc/1300-7777; https://doaj.org/toc/1308-5263 |
| URL الوصول: | https://doaj.org/article/a712b3db6a124d7f9150ca8a57478276 |
| رقم الأكسشن: | edsdoj.712b3db6a124d7f9150ca8a57478276 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13007777 13085263 |
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