دورية أكاديمية
The frequency of Tim-3 on circulating Tfh cells was increased in type 2 diabetes mellitus patients
| العنوان: | The frequency of Tim-3 on circulating Tfh cells was increased in type 2 diabetes mellitus patients |
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| المؤلفون: | Shuai Guo, Xujie Yu, Limei Wang, Jing Jing, Yuanyuan Sun, Na Li, Jiangying Kuang, Di Zhao, Xingyu Yu, Jingjing Yang, Wenjiang Yan |
| المصدر: | European Journal of Inflammation, Vol 18 (2020) |
| بيانات النشر: | SAGE Publishing, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | Type 2 diabetes mellitus (T2DM) is a chronic, low-grade inflammation disease. T follicular helper (Tfh) cells and T cell immunoglobulin and mucin domain 3 (Tim-3) are implicated in many immune diseases. This study aims to explore whether Tim-3 expression on Tfh cells is associated with T2DM progression. White blood cells (WBCs) were harvested from 30 patients with T2DM and 20 healthy donors. The abundance of circulating Tfh cells (cTfh) and the frequency of Tim-3 were analyzed by flow cytometry. Levels of fasting plasma glucose (FPG), insulin, hemoglobin A1C (HbA1C), and fasting plasma C-peptide were measured. Body mass index (BMI) and diabetes duration were also recorded. Patients with T2DM had higher numbers of cTfh cells. In addition, cTfh cells showed a negative correlation with HbA1C and diabetes duration, a positive correlation with fasting plasma C-peptide. The frequency of Tim-3 on cTfh cells was higher among T2DM patients compared with healthy donors. The in vitro experiment showed that high glucose levels increased the abundance cTfh cells but had no effect on Tim-3 expression. Our results suggest that cTfh cells and associated Tim-3 frequency may contribute to the progression of T2DM, and high glucose levels may influence cTfh cells directly. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2058-7392 20587392 |
| Relation: | https://doaj.org/toc/2058-7392 |
| DOI: | 10.1177/2058739220982803 |
| URL الوصول: | https://doaj.org/article/712c20f54a184205809860a77333e4b0 |
| رقم الأكسشن: | edsdoj.712c20f54a184205809860a77333e4b0 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20587392 |
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| DOI: | 10.1177/2058739220982803 |