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Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice.

التفاصيل البيبلوغرافية
العنوان: Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice.
المؤلفون: Caroline M Ferreira, James L Chen, Jianrong Li, Kazuhiro Shimomura, Xinan Yang, Yves A Lussier, Lawrence H Pinto, Julian Solway
المصدر: PLoS ONE, Vol 7, Iss 1, p e29579 (2012)
بيانات النشر: Public Library of Science (PLoS), 2012.
سنة النشر: 2012
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: We used two-dimensional quantitative trait locus analysis to identify interacting genetic loci that contribute to the native airway constrictor hyperresponsiveness to methacholine that characterizes A/J mice, relative to C57BL/6J mice. We quantified airway responsiveness to intravenous methacholine boluses in eighty-eight (C57BL/6J X A/J) F₂ and twenty-seven (A/J X C57BL/6J) F₂ mice as well as ten A/J mice and six C57BL/6J mice; all studies were performed in male mice. Mice were genotyped at 384 SNP markers, and from these data two-QTL analyses disclosed one pair of interacting loci on chromosomes 11 and 18; the homozygous A/J genotype at each locus constituted the genetic interaction linked to the hyperresponsive A/J phenotype. Bioinformatic network analysis of potential interactions among proteins encoded by genes in the linked regions disclosed two high priority subnetworks--Myl7, Rock1, Limk2; and Npc1, Npc1l1. Evidence in the literature supports the possibility that either or both networks could contribute to the regulation of airway constrictor responsiveness. Together, these results should stimulate evaluation of the genetic contribution of these networks in the regulation of airway responsiveness in humans.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3254621?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0029579
URL الوصول: https://doaj.org/article/7184d07249a74cc0bb762d62b3ce4785
رقم الأكسشن: edsdoj.7184d07249a74cc0bb762d62b3ce4785
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0029579